TEST PhD candidate 'Pancreatic ductal adenocarcinoma'

Job description
A hallmark of PDAC is its abundant and complex tumor stroma, which not only supports tumor progression but also forms a major barrier to effective treatment. Conventional therapies, including chemotherapy and even the most advanced immunotherapies, have shown limited clinical benefit for many patients.

This position offers a unique opportunity to contribute to impactful research that may ultimately improve outcomes for patients with pancreatic cancer.

As a PhD candidate, you will:

• Design and conduct experimental studies on stromal biology in PDAC.
• Develop and test peptide- and nano-based targeted therapeutic strategies.
• Work with in vitro and in vivo PDAC models.
• Analyze and interpret experimental data and present findings at meetings and conferences.
• Contribute to scientific publications and your PhD thesis.
• Collaborate closely with multidisciplinary team members, including biologists, clinicians, and pharmaceutical scientists.

Place of work
You will be embedded in a dynamic and international research group at Department of Medical Biosciences, Radboud university medical center (Radboudumc) in Nijmegen, a leading center for patient care, biomedical research, and education. The hosting department has strong expertise in cancer biology, translational oncology, and drug development, and provides access to state-of-the-art facilities and core platforms.

You will work in a collaborative environment where basic scientists and clinicians closely interact, enabling real translational impact. The team consists of motivated PhD candidates, postdocs, technicians, and clinician-scientists who support each other’s development and success.

Medical BioSciences is a science department where fundamental and translational biomedical research come together. You will study disease and health from the molecular level to clinical application, with a strong focus on medical innovation. Researchers work closely with clinicians to translate new insights into better diagnostics and treatments. Using experimental and data-driven approaches, we study biochemical, cellular, and physiological processes in health and disease.

Test Elke Postdoc 'Neuroimaging of the Substantia Nigra in Parkinson's disease'

Job description
This consortium brings together leading institutions across Europe, Canada, and Israel, including Radboud University and Radboudumc (The Netherlands), Sorbonne University (France), McGill University and the University of Montreal (Canada), Macquarie University (Australia), Tel-Aviv Sourasky Medical Center (Israel), and the University of Lübeck (Germany). ((https://www.radboudumc.nl/en/vacancies/160668-postdoc-neuroimaging-of-the-substrantia-nigra-in-parkinsons-disease))

You will be embedded at Radboud University/Radboudumc in Nijmegen, working at the intersection of three research groups:

• Systems Neurology (Dr. Rick Helmich) – internationally recognized for innovative neuroimaging and neuromodulation studies in Parkinson’s disease.
• Prevention of Parkinson’s Disease (Dr. Sirwan Darweesh) – with unique expertise on prodromal stages of Parkinson’s disease, e.g. individuals with isolated REM-sleep Behavioural Disorder.
• MR Structural Quantitative Imaging (Dr. José Marques) – a leading team in developing advanced quantitative MRI methods for clinical and population-based applications.

This unique environment offers access to cutting-edge technology, large multi-site MRI datasets (multiple sites, >1,000 patients with early Parkinson, ~100 people with iRBD, with data acquired longitudinally), deep interdisciplinary expertise (data with rich clinical phenotyping), and a collaborative international network with large opportunities for networking. Within this consortium, the Nijmegen team will focus on the analysis of quantitative susceptibility mapping (QSM) MRI data to measure iron-sensitive (longitudinal) structural changes in the substantia nigra of people with prodromal (iRBD) and symptomatic Parkinson’s disease. To this end, data from all international partners will be used.

Tasks and responsibilities
In this role, you will take a leading part in developing and deploying quantitative MRI biomarkers of nigral degeneration. Your responsibilities include:

• Develop and implement longitudinal QSM analysis methods that fully exploit multi-time-point data.
• Build fast visual quality-control tools using BIDScoin for efficient curation of multi-site datasets.
• Create alternative R2* and QSM-based biomarkers of nigral dysfunction using robust substantia nigra segmentation.
• Develop advanced normative modelling approaches to account for population and inter-site variability.
• Coordinate with other work-package leaders to align biomarker extraction across diffusion, neuromelanin, and QSM imaging and coordinate data transfer between sites.
• Maintain reproducible, open, and FAIR-compliant analysis workflows throughout the project.

Place of work
The Donders Centre for Cognitive Neuroimaging (DCCN) is a top scientific institute that forms an integral part of the broader Donders Institute for Brain, Cognition and Behaviour at Radboud University. The mission of the DCCN is to conduct cutting-edge fundamental research in cognitive neuroscience. Much of the rapid progress in this field is being driven by the development of complex neuroimaging techniques for measuring activity in the human brain – an area in which the DCCN plays a leading role.

In addition to its strong methodological focus, the DCCN fosters close collaboration between researchers from diverse disciplines, including neuroscience, psychology, physics, and computer science. This interdisciplinary environment enables innovative approaches to understanding brain function and supports the development of new analytical tools and experimental paradigms.

The DCCN also aims to establish how the different brain areas coordinate their activity with very high temporal precision to enable human and animal cognition. The DCCN is equipped with 4 MRI scanners (1 × 7T, 2 × 3T), a 275-channel MEG system, an EEG-TMS laboratory, several MR-compatible EEG systems, equipment for transcranial direct/alternating/magnetic stimulation, and high-performance computational facilities. An MRI-compatible system for neuromodulation using transcranial ultrasound stimulation is currently being installed and piloted in collaboration with teams at the Donders Centre for Cognition.

Our internationally renowned centre currently hosts more than 100 PhD candidates and postdoctoral researchers from more than 25 countries, offering a stimulating and multidisciplinary research environment.

comms cv motivatie meeloopdag na alle docs mogelijk assess

Job description
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Place of work
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Bij de afdeling Anesthesiologie, Pijn en Palliatieve Geneeskunde werk je aan veilige, betrouwbare en patiëntgerichte zorg vóór, tijdens en na operaties. Je draagt bij aan de preoperatieve beoordeling, kiest samen met patiënten de meest passende vorm van anesthesie en zorgt tijdens ingrepen voor optimale bewaking van vitale functies. Daarnaast behandel je chronische pijn en ondersteun je patiënten met ongeneeslijke ziekte en hun naasten met advies, pijnbestrijding en palliatieve zorg. Je werkt nauw samen met collega’s uit verschillende specialismen — onder andere in de preoperatieve polikliniek, op de operatiekamers en binnen het pijn- en palliatieve behandelcentrum — om continu de kwaliteit en veiligheid van zorg te verbeteren. De afdeling biedt daarnaast consultatie en ondersteuning aan huisartsen, specialisten en verpleegkundigen bij complexe zorgvragen. Met aandacht voor individuele behoeften en samenwerking in multidisciplinaire teams help je de zorg van morgen vorm te geven.

TEST Postdoc 'Neuroimaging of the Substantia Nigra in Parkinson's disease'

Job description

We are looking for an ambitious and creative postdoc to join an international project titled 'Evaluation of neuromelanin-sensitive imaging, quantitative susceptibility mapping, and free-water imaging as biomarkers of nigral dopaminergic dysfunction'. The goal of this project is to develop and validate new MRI-based biomarkers for (prodromal) Parkinson’s disease and compare QSM with other MRI-based outcomes (i.e. neuromelanin-sensitive MRI that is analysed in Paris and free-water MRI that is analysed in Montreal).

This consortium brings together leading institutions across Europe, Canada, and Israel, including Radboud University and Radboudumc (The Netherlands), Sorbonne University (France), McGill University and the University of Montreal (Canada), Macquarie University (Australia), Tel-Aviv Sourasky Medical Center (Israel), and the University of Lübeck (Germany).

You will be embedded at Radboud University/Radboudumc in Nijmegen, working at the intersection of three research groups:

• Systems Neurology (Dr. Rick Helmich) – internationally recognized for innovative neuroimaging and neuromodulation studies in Parkinson’s disease.
• Prevention of Parkinson’s Disease (Dr. Sirwan Darweesh) – with unique expertise on prodromal stages of Parkinson’s disease, e.g. individuals with isolated REM-sleep Behavioural Disorder.
• MR Structural Quantitative Imaging (Dr. José Marques) – a leading team in developing advanced quantitative MRI methods for clinical and population-based applications.

This unique environment offers access to cutting-edge technology, large multi-site MRI datasets (multiple sites, >1,000 patients with early Parkinson, ~100 people with iRBD, with data acquired longitudinally), deep interdisciplinary expertise (data with rich clinical phenotyping), and a collaborative international network with large opportunities for networking. Within this consortium, the Nijmegen team will focus on the analysis of quantitative susceptibility mapping (QSM) MRI data to measure iron-sensitive (longitudinal) structural changes in the substantia nigra of people with prodromal (iRBD) and symptomatic Parkinson’s disease. To this end, data from all international partners will be used.

Tasks and responsibilities
In this role, you will take a leading part in developing and deploying quantitative MRI biomarkers of nigral degeneration. Your responsibilities include:

• Develop and implement longitudinal QSM analysis methods that fully exploit multi-time-point data.
• Build fast visual quality-control tools using BIDScoin for efficient curation of multi-site datasets.
• Create alternative R2* and QSM-based biomarkers of nigral dysfunction using robust substantia nigra segmentation.
• Develop advanced normative modelling approaches to account for population and inter-site variability.
• Coordinate with other work-package leaders to align biomarker extraction across diffusion, neuromelanin, and QSM imaging and coordinate data transfer between sites.
• Maintain reproducible, open, and FAIR-compliant analysis workflows throughout the project.

Place of work
The Donders Centre for Cognitive Neuroimaging (DCCN) is a top scientific institute that forms an integral part of the broader Donders Institute for Brain, Cognition and Behaviour at Radboud University. The mission of the DCCN is to conduct cutting-edge fundamental research in cognitive neuroscience. Much of the rapid progress in this field is being driven by the development of complex neuroimaging techniques for measuring activity in the human brain – an area in which the DCCN plays a leading role.

In addition to its strong methodological focus, the DCCN fosters close collaboration between researchers from diverse disciplines, including neuroscience, psychology, physics, and computer science. This interdisciplinary environment enables innovative approaches to understanding brain function and supports the development of new analytical tools and experimental paradigms.

The DCCN also aims to establish how the different brain areas coordinate their activity with very high temporal precision to enable human and animal cognition. The DCCN is equipped with 4 MRI scanners (1 × 7T, 2 × 3T), a 275-channel MEG system, an EEG-TMS laboratory, several MR-compatible EEG systems, equipment for transcranial direct/alternating/magnetic stimulation, and high-performance computational facilities. An MRI-compatible system for neuromodulation using transcranial ultrasound stimulation is currently being installed and piloted in collaboration with teams at the Donders Centre for Cognition.

Our internationally renowned centre currently hosts more than 100 PhD candidates and postdoctoral researchers from more than 25 countries, offering a stimulating and multidisciplinary research environment.

You will be working in the department of IQ Health. A department that is very active in teaching, research and consultation/service delivery.

IQ Health originated from the former departments of Health Evidence and IQ healthcare. IQ Health is a state-of-the-art research and teaching centre, where methods of research are themselves the subject of study and development. Through education and consultation (services), we help Radboudumc as well as external organisations in applying the right methods of research.

Preventing illness, improving care! In this way we contribute to the mission of the Radboudumc; To have a significant impact on health and healthcare. The IQ Health department employs about 200 colleagues. The heart of the IQ Health department consists of six Research & Education (R&E) groups. These groups work together internally and externally (nationally and internationally) on topical themes and are connected to the two core tasks of education and research. In addition, the groups provide external consultation. See also our Flyer Supervision of doctoral students and 10 Prerequisite for the supervision of a PhD program within IQ Health to find out how our PhD program is outlined. The aim is to deploy PhD candidates in education for 10%.

Secretarieel medewerker patiëntenzorg Intensive Care

Functie

Als secretarieel medewerker patiëntenzorg ben je verantwoordelijk voor het efficiënte verloop van het patiëntenzorgproces. Wil je met jouw vermogen om vooruit en mee te denken zorgdragen voor optimale ondersteuning en eraan bijdragen dat werkzaamheden en activiteiten tijdig worden ingepland en uitgezet? Dan zijn wij op zoek naar jou!

Het patiëntenzorgsecretariaat van de afdeling Intensive Care bestaat uit een team met daarin een Front- en BackOffice. Als secretarieel medewerker patiëntenzorg ben je verantwoordelijk voor alle secretariële, administratieve en organisatorische ondersteuning ten behoeve van het primaire proces. Je houdt het overzicht en bent in staat om tijdig te signaleren.

Je bent betrokken en voelt je verantwoordelijk voor de optimale inrichting van de werkzaamheden die hieraan verbonden zijn. Je toont initiatief en bent in staat om de dialoog aan te gaan met anderen. Door je professionele optreden in samenwerking met de collega’s van de Front- en Bac

Jouw werkplek
Als secretarieel medewerker patiëntenzorg ben je binnen het secretariaat inzetbaar voor onze verschillende Intensive Care en Medium Care afdelingen. We werken samen met de BackOffice en het Planbureau, teamleiders, zorgmanagers en hebben contact met het Stafsecretariaat.

We zijn een hecht en enthousiast team waarbij we op een prettige en collegiale manier werken aan het doorlopend verder verbeteren van de zorg voor onze patiënten en daarbij behorende processen.

De IC van het Radboudumc is een onderdeel van het centrum Acuut en Intensieve zorg. Naast verbeteringen in de ketenzorg werken we ook vaker samen op secretarieel niveau met alle afdelingen binnen dit centrum.

Bij het Radboudumc Centrum voor Acute en Intensieve Zorg werk je in de frontlinie van de zorg. In een dynamische, academische omgeving verleen je topklinische acute en intensieve zorg aan acuut zieke en instabiele patiënten. Samen met ervaren teams maak je het verschil in situaties waarin snelle besluitvorming en hoogtechnologische behandelingen levensreddend zijn. Binnen het centrum zijn spoedeisende zorg, intensive care en invasieve interventies optimaal op elkaar afgestemd. Zorg, opleiding, onderwijs en onderzoek komen hier samen, waardoor innovatie direct bijdraagt aan betere protocollen en behandelmethoden. In nauwe samenwerking met partners binnen het academisch netwerk vervult het centrum een faciliterende rol, met als doel de best mogelijke zorg op het moment dat het er écht toe doet.