ANIOS Psychiatrie | Expertisecentrum voor Mindfulness

Ben je geïnteresseerd in een academische loopbaan met onderzoeks- of onderwijsactiviteiten? Op onze afdeling krijg je volop inzicht in de vele verschillende facetten van de academische psychiatrie.

Als ANIOS psychiatrie werk je op een dynamische afdeling waar patiëntenzorg, wetenschappelijk onderzoek en onderwijs hand in hand gaan. In de huidige ANIOS functie ondersteun je voornamelijk de patiëntenzorg in het Expertisecentrum voor Mindfulness. Je zult betrokken zijn bij de intakes, diagnostiek en indicatiestelling voor behandeling.

Binnen deze werkzaamheden leer je alle kanten van het vak goed kennen: het diagnostische proces, de invloed van psychosociale factoren, biologische en psychotherapeutische behandelopties, en de aanpak van multidisciplinaire behandelteams. De zorgtrajecten op onze afdeling zijn vaak complex, zowel psychiatrisch-inhoudelijk, als qua (somatische) comorbiditeit en samenwerking met andere organisaties en specialismen. Het is daarom belangrijk dat je goed overzicht kan behouden en stevig in je schoenen staat.

Het Expertisecentrum voor Mindfulness is bovendien volop betrokken bij wetenschappelijk onderzoek. Door participatie in (internationale) onderzoeken en door initiatie van eigen onderzoek, zoals het onderzoeken van het effect van mindfulness als vroege interventie bij jongeren met psychische klachten.

Na je inwerkperiode, zul je als ANIOS ook meedraaien in de bereikbaarheidsdiensten

PhD candidate 'Bridging the Gap: Exploring Missing Heritability in Rare Diseases'

We are seeking a highly motivated PhD candidate to join our research team working at the intersection of genomics, rare diseases, and genetic tumor risk syndromes. The project focuses on the identification and interpretation of genomic variants to unravel disease mechanisms in patients with suspected genetic disorders or hereditary cancer predispositions.

Using large-scale next-generation sequencing (NGS) data, you will contribute to the discovery of novel disease genes, the interpretation of variant pathogenicity, and the elucidation of underlying molecular pathways. The work will involve close collaboration between clinicians, bioinformaticians, and molecular biologists in an interdisciplinary and translational research environment.

Tasks and responsibilities

• Analyzing and interpreting NGS data, including short- and long-read whole-genome sequencing (WGS) and whole-exome sequencing (WES) data, to identify post-zygotic and germline variation, structural variation, and other genomic abnormalities.
• Design and perform scientific research in the area of rare diseases, particularly genetic tumor risk syndromes.
• Present findings at local and (inter)national scientific meetings.
• Collaborate with researchers within European Reference Networks (ERN) and the European Rare Diseases Research Alliance (ERDERA; erdera.org).
• Work in an interdisciplinary team with other students and scientists to discuss, plan, and perform research.
• Finish the project with a scientific dissertation.

This position offers a dynamic and supportive research environment with ample opportunities for professional and academic development.

Postdoc 'Behavioural theory during pandemics: International Expert Consensus Study'

If you want to work on an exciting, international project for advancing behavioural science theory and expand your international network with top scholars, then this could be the right project for you. You will be working with colleagues from IQ Health (Implementation and Behavioural Science group) at Radboudumc and with behavioural science colleagues from the RIVM (the Dutch public health institute).

You will be the lead researcher on a project with the aim to develop, through expert consensus procedures, a more robust theoretical framework for infection prevention behaviour during major infectious disease outbreaks (including pandemics). A theoretical framework that does not only focus on individual behaviour, but also the social, physical, and policy context.

Background Information
In the past years, many researchers have investigated which factors influenced public adherence to COVID-19 prevention measures, such as physical distancing or testing for COVID-19. Often these studies were informed by prevention-focused behavioral theories, such as the health belief model or protection motivation theory. These theories were, however, untested in the context of pandemics. Moreover, their scope is limited primarily to individuals' beliefs and affect, largely ignoring the social and physical context and its dynamics influencing prevention behavior. A more comprehensive theoretical framework describing infection prevention behaviors during pandemics could be of great value during a future outbreak.

Now, several years after the pandemic, there is a substantial empirical literature on drivers of infection prevention behaviors during a pandemic. In this postdoctoral project, you will be part of a research collaboration that collates this evidence. You will be responsible for conducting an international expert consensus study to examine whether and how our theoretical model(s) need to be improved to better capture the key drivers of infection prevention behaviors during an infectious disease outbreak. This project is also part of the BePrepared consortium.

What we offer
We offer an exciting opportunity to work in a collaborative, social, and dedicated team of researchers from multiple institutions. You will build a strong national and international network of top scholars in the behavioral sciences. The results of your work will be relevant both from a scientific perspective as well as for preparedness activities. For example, the results will be submitted to the RIVM's pandemic preparedness toolkit, and we will seek collaboration with and dissemination through organizations internationally, such as the WHO and ECDC.

Postdoc 'Point of care CAR-T cell production’

Interested in Immunology and Immunotherapy for cancer? Join our exciting translational research group! For our expanding translational research group we are looking for an ambitious Postdoc that is interested Advanced Therapy Medicinal Products and CAR-T cells.

As a Postdoc you will work together with researchers and (research)technicians to implement CAR-T cell manufacturing in our GMP facility to treat patients with diffuse large B-cell lymphoma.

You will coordinate the implementation of the project and be involved in writing and reviewing GMP documentation, risk assessments, manufacturing and QC documentation. You will be part of our expert ATMP and QC team and be responsible for preparing batch records, deviations and change control in close collaboration with the Qualified Persons from the Pharmacy department.

You will also actively be part of the production team involved in manufacturing of the CAR-T cells in our class B cleanroom environment, quality control testing and equipment and cleanroom monitoring and maintenance.

You will be required to work on-site.

Bioinformatics Developer and Data Analyst

Biomedical and genomics research is becoming more and more complex. The data that is being generated in modern biomedical research is growing exponentially, and is also growing in importance. Are you the Bioinformatics developer and data analyst we are looking for to support researchers and build better tools for data driven research at the Radboudumc Technology Center (RTC) Bioinformatics? We would like to get to know you!

As a bioinformatics developer and analyst, you will work together with scientists and other data experts to deliver bioinformatics data analysis, infrastructure and support to the various departments within the Radboudumc. You will focus on implementing state-of-the-art tools and build scalable bioinformatics pipelines. You will assist in the interpretation of the data and discuss the results with (bio)medical researchers.

One of the unique aspects of this position is that you will be involved in many diverse and innovative research projects that take place in all the departments of the Radboudumc. You will preform research analysis that can both contribute to fundamental science and direct impact on our patient's well being. You will get the freedom to work independently and develop your own bioinformatics and data science skills. Flexible work home office schedules are optional, with fixed in-office days.

Tasks

• Preprocessing, quality control, downstream processing, visualization and interpretation of omics data.
• Plan, create and execute bioinformatics data analysis and research projects.
• Work with omics data ranging from single cell RNA seq to deep sequencing variant calling.
• Development new data analysis pipelines and implement new bioinformatics methods.
• Translate complex datasets and results to (bio)medical researchers and stakeholders.
• Working on diverse computational platforms like clusters and the cloud.
• Documentation and versioning of code and maintenance of systems.