Lab Manager (Part-time or full time)

The Tanenbaum lab studies how cells and viruses control gene expression at the level of mRNA regulation. We develop and apply advanced microscopy approaches that allow us to visualize the translation and regulation of individual mRNA molecules in living cells. Our work combines quantitative live‑cell imaging, molecular biology, and genetic engineering to uncover the molecular mechanisms that control gene expression in human cells and during RNA virus infection. Using these approaches, we aim to understand how gene expression dynamics shape cellular behavior and disease processes.

We are looking for a motivated and organized lab manager to support our research program. The position combines experimental work with laboratory organization and management. The successful candidate will work closely with members of the Tanenbaum lab and collaborate with other research groups and facilities at the Hubrecht Institute.

Responsibilities
The lab manager will support the daily operation of the laboratory and contribute to research projects. Tasks will include:

• Performing molecular biology and cell culture experiments
• Supporting live‑cell microscopy experiments, sample preparation and analysis
• Assisting with cloning, cell line generation, and assay development
• General laboratory organization (ordering, inventory, equipment coordination)
• Helping maintain laboratory protocols and documentation
• Supporting lab members with experimental setup and troubleshooting

PostDoc - Hubrecht Institute - Utrecht

In the framework of a ZonMW-funded project entitled: “Translational strategies for lymphatic anomalies in RASopathies”, there is an opening for a postdoc in the den Hertog lab. The RASopathies form a group of human syndromes that are characterized by similar symptoms (short stature, craniofacial defects, cardiac defects and enhanced susceptibility to cancer) and are caused by activating mutations in factors of the RAS-MAPK signaling pathway. Noonan syndrome (NS) is one of the most common RASopathies and 50% of NS patients have an activating mutation in SHP2, a protein-tyrosine phosphatase encoded by the PTPN11 gene. To understand the molecular-genetic and cellular basis of NS at the organismal level, we study zebrafish. We have introduced mutations in zebrafish ptpn11 and other NS-associated genes, sos1 and sos2, using CRISPR/Cas9 technology and Homology-Directed Repair. Initial characterization suggested that these zebrafish NS models recapitulate symptoms in human NS patients. In this project, the focus will be on defects in the lymphatic vasculature, which is a major problem in human NS patients. We will investigate genotype/phenotype correlations in zebrafish NS models and study the mechanism underlying defects in the lymphatic vasculature. Moreover, we will use therapeutic drugs to ameliorate the lymphatic defects in zebrafish NS models. This approach will highlight how pharmacological intervention rescues development of lymphatic structures.

Lab manager - Hubrecht Institute - Utrecht

Research Environment
Living systems are composed of individual cells, yet even genetically identical cells exhibit substantial heterogeneity in their molecular states, histories, and responses to environmental cues. This intrinsic variability underlies fundamental biological processes, including developmental decision-making, tissue homeostasis, disease progression, and therapeutic resistance.

The van Oudenaarden lab develops experimental and computational technologies to interrogate biological processes at single-cell resolution. Our work spans multiple layers of the central dogma, including genome replication, transcription, and translation. By moving beyond population-averaged measurements, we directly observe molecular variability, regulatory dynamics, and functional heterogeneity.

Through the development of novel experimental protocols and analytical frameworks, we enable quantitative single-cell measurements that were previously inaccessible, providing deeper insight into how molecular processes generate cellular diversity.

Role and Responsibilities
The Lab Manager / Technician will:

• Perform and optimize molecular biology and cell culture experiments
• Contribute to the development and implementation of novel sequencing protocols
• Support laboratory organization, procurement, and inventory management
• Maintain equipment and coordinate laboratory infrastructure
• Collaborate closely with lab members and other researchers within the institute
• Contribute to a well-organized, efficient, and high-quality research environment

Team lead/ Analist HLO - Westerdijk Institute - Utrecht

De wereldvermaarde schimmelcollectie van het Westerdijk Fungal Biodiversity Institute zoekt een ervaren analist en teamleider van de preservatie-analisten. Je draagt bij aan de opname, preservatie en kwaliteitscontrole van schimmels in de Biobank die door wetenschappers in meer dan 60 landen wordt gebruikt voor onderzoek en als referentiemateriaal. Je werkt nauw samen met de schimmelcurator, conform de hoge kwaliteitseisen van een ISO 9001-certificaat.

Dit ga je doen

• Samen met het analistenteam preserveren en beheren van voorraden van de schimmelcollectie.
• Nieuw ontvangen schimmelstammen opkweken en in samenwerking met de curator beoordelen op reinheid, vitaliteit en geschiktheid voor opname.
• Ontvangen documenten en data over stammen controleren, invoeren en archiveren.
• Corresponderen met depositors over praktische zaken.
• Stammen voorzien van CBS culture-nummers.
• Uitvoeren en registreren van kwaliteitscontroles d.m.v. DNA-sequencing en andere analyses.
• Toezicht houden op het proces voor opname en preservatie van het ISO-kwaliteitsmanagementsysteem en bijdragen aan de verbetering van werkprocedures en de implementatie van nieuwe methoden.

Applicatie- en databasebeheerder - NIOO-KNAW - Wageningen

Het team van Vogeltrekstation regelt de dagelijkse gang van zaken rond het vangen en ringen van vogels voor wetenschappelijk onderzoek, beleid en bescherming. Als applicatie- en databasebeheerder beheer je onze webapplicatie ‘GRIEL’, waarvan de backend gebouwd is in C# en de frontend in Javascript. Onderliggend draait een een Microsoft SQL-Server database. Via de applicatie kunnen geregistreerde eindgebruikers ring- en terugmeldgegevens van vogels invoeren, bekijken, beheren en exporteren.

Naast het beheer van de applicatie en de database bestaan de werkzaamheden uit het ondersteunen van eindgebruikers. Tevens voer je kleine functionele aanpassingen uit aan de applicatie en database en begeleid je grotere aanpassingen die nodig zijn om de applicatie up-to-date en compatibel te houden in nauwe samenwerking met derden.