PostDoc on Targeted Proteomics for Protein Biomarker Standardization

Introduction
Are you eager to translate cutting-edge targeted proteomics into standardized protein biomarker measurements for clinical diagnostics? Join an interdisciplinary academic-clinical-industry collaboration developing robust LC-MS/MS reference methods for lung cancer tumor markers.

Job Description
The challenge
Protein tumor markers can support minimally invasive lung cancer diagnostics, but results from current immunoassays vary between platforms and laboratories. You will help close this standardization gap by developing and validating targeted mass-spectrometry workflows and reference measurement procedures for clinically relevant protein biomarkers, including CEA, NSE and CYFRA21-1.

Your role
You will conduct hands-on research in quantitative targeted proteomics, with emphasis on immunoaffinity enrichment, bottom-up LC-MS/MS and SISCAPA-based workflows. You will select and evaluate signature peptides, establish calibration strategies using stable-isotope-labelled standards, characterize reference proteins and peptides, and assess sensitivity, selectivity, recovery, matrix effects, precision, accuracy and robustness. You will compare candidate reference methods with commercial immunoassays and contribute to analysis of serum and pleural-fluid samples.

You will integrate activities across connected projects that aim to create a transferable platform for reference measurement procedures and materials for complex protein biomarkers. You will plan experiments, maintain high-quality and reproducible documentation, analyze and interpret quantitative data, prepare scientific publications and presentations, and contribute to method transfer, standard operating procedures and project reporting.

Research environment and collaboration
The position is embedded in the Laboratory of Chemical Biology, Department of Biomedical Engineering at Eindhoven University of Technology (TU/e), and in the regional Expertise Center Clinical Chemistry Eindhoven. You will work closely with researchers and clinical chemists at TU/e, Catharina Hospital and Máxima Medical Center, and with diagnostic and technology partners including Roche Diagnostics and SISCAPA Assay Technologies. You will also collaborate with PhD students and supervise Master and Bachelor students.

Expected impact
Your work will advance metrologically traceable and comparable protein biomarker measurements, support harmonization of tumor-marker testing across clinical laboratories, and establish methods that can be extended to biomarkers beyond lung cancer.

Job Requirements

• A PhD in analytical chemistry, proteomics, biochemistry, chemical biology, clinical chemistry, biomedical engineering, or a closely related field.
• Demonstrable hands-on research experience in (targeted quantitative) proteomics, LC-MS/MS bioanalysis and/or quantitative protein biomarker analysis.
• Experience with triple-quadrupole mass spectrometry and quantitative acquisition strategies such as MRM/SRM or PRM.
• Experience with protein and peptide sample preparation, enzymatic digestion, immunoaffinity enrichment and/or stable-isotope-labelled internal standards. Experience with SISCAPA, automated liquid handling, protein engineering or recombinant protein production is an advantage.
• Sound knowledge of analytical method development and validation, including calibration, sensitivity, selectivity, precision, accuracy, recovery, matrix effects, robustness, quality control and measurement uncertainty.
• Ability to conduct high-quality independent research, demonstrated through publications or other substantial research outputs.
• Strong quantitative and problem-solving skills, careful experimental practice.
• Ability to manage complex work packages, prioritize activities and deliver results on schedule.
• A collaborative and proactive working style, with the ability to communicate effectively across academic, clinical and industrial disciplines and to support junior researchers.
• Excellent written and spoken English. Knowledge of Dutch is not required, but willingness to collaborate effectively with Dutch clinical and academic environments is expected.

Conditions of Employment
A meaningful job in a dynamic and ambitious university, in an interdisciplinary setting and within an international network. You will work on a beautiful, green campus within walking distance of the central train station.

In addition, we offer you:

• Full-time employment for 2 years.
• Salary in accordance with the Collective Labour Agreement for Dutch Universities, scale 10, ranging from € 4,422 (step 4) to € 5,760 gross base salary per month (full-time).
• In addition to your base salary, you will receive an 8% holiday allowance and an 8.3% year-end bonus, both calculated based on your annual gross base salary.
• Generous leave options: a standard 29 days (based on a 38 hour working week) per year that you can increase to 41 days by working two hours more per week (flexible working hours). This is prorated if you work part-time.
• As a TU/e employee, you participate in the ABP pension scheme, providing retirement pension and pension benefits for surviving dependents and occupational disability. TU/e pays 70% of the pension premium, while employees contribute the remaining 30%.
• High-quality training programs on general skills, didactics and topics related to research and valorization.
• An excellent technical infrastructure, and on-campus children's day care.
• Unlimited access to the modern on‑campus TU/e Student Sports Center at an exceptionally affordable rate.
• We support your wellbeing with free 24/7 access to OpenUp, providing you and your family with mental health support, expert guidance, and online training.
• Partially paid parental leave and an allowance for commuting, working from home and internet costs.
• A TU/e Postdoc Association that helps you to build a stronger and broader academic and personal network, and offers tailored support, training and workshops.
• A Staff Immigration Team is available for international candidates, as are a tax compensation scheme (the Expat Scheme) and a compensation for moving expenses.

On our website you can discover even more information about our conditions of employment. Build on your career at TU/e!

About us
We are a leading international university where scientific curiosity meets a hands-on mindset. We work in an open and collaborative way with high-tech industries to tackle complex societal challenges. Our responsible and respectful approach ensures impact — today and in the future. TU/e is home to over 13,000 students and more than 7,000 staff, forming a diverse and vibrant academic community. Discover what Light Up means to TU/e in our short company video.

Our university is located in Brainport Eindhoven — a world‑leading tech region with more than 7,000 high‑tech companies and strong R&D activity. Known for breakthroughs in AI, photonics, semiconductors and advanced manufacturing, Brainport is a place where technology serves people and society. Learn more about the Brainport region here.

The Department of Biomedical Engineering offers top-level education and research in one of the most relevant and exciting scientific disciplines of the 21st century: engineering health. In combining engineering and life sciences, through challenge-based learning and a multidisciplinary approach in collaboration with hospitals, industry and others, the department addresses the great challenges of the future, striving to improve healthcare and society as a whole.

Information
Do you recognize yourself in this profile and would you like to know more? Please contact the hiring manager Luc Brunsveld, Professor of Chemical Biology, l.brunsveld@tue.nl or +31 40 2472870.

Visit our website for more information about the application process. You can also contact HRServices.bme@tue.nl.

Are you inspired and would like to know more about working at TU/e? Please visit our career page.

Application
We invite you to submit a complete application using the apply-button. The application should include a:

• Cover letter in which you describe your motivation and qualifications for the position.
• Curriculum vitae, including a list of your publications and the contact information of three references. Kindly note that we may reach out to references at any stage of the recruitment process. We recommend notifying your references upon submitting your application.
• List of up to five self-selected ‘best publications’.

Ensure that you submit all the requested application documents. Please note that incomplete applications may not be considered and could be rejected.

We look forward to receiving your application and will screen it as soon as possible. The vacancy will remain open until the position is filled.

Please note

• You can apply online. We will not process applications sent by email and/or post.
• A pre-employment screening (e.g. knowledge security check) can be part of the selection procedure. For more information on the knowledge security check, please consult the National Knowledge Security Guidelines.
• Please do not contact us for unsolicited services.

PostDoc on Targeted Proteomics for Protein Biomarker Standardization

The challenge
Protein tumor markers can support minimally invasive lung cancer diagnostics, but results from current immunoassays vary between platforms and laboratories. You will help close this standardization gap by developing and validating targeted mass-spectrometry workflows and reference measurement procedures for clinically relevant protein biomarkers, including CEA, NSE and CYFRA21-1.

Your role
You will conduct hands-on research in quantitative targeted proteomics, with emphasis on immunoaffinity enrichment, bottom-up LC-MS/MS and SISCAPA-based workflows. You will select and evaluate signature peptides, establish calibration strategies using stable-isotope-labelled standards, characterize reference proteins and peptides, and assess sensitivity, selectivity, recovery, matrix effects, precision, accuracy and robustness. You will compare candidate reference methods with commercial immunoassays and contribute to analysis of serum and pleural-fluid samples.

You will integrate activities across connected projects that aim to create a transferable platform for reference measurement procedures and materials for complex protein biomarkers. You will plan experiments, maintain high-quality and reproducible documentation, analyze and interpret quantitative data, prepare scientific publications and presentations, and contribute to method transfer, standard operating procedures and project reporting.

Research environment and collaboration
The position is embedded in the Laboratory of Chemical Biology, Department of Biomedical Engineering at Eindhoven University of Technology (TU/e), and in the regional Expertise Center Clinical Chemistry Eindhoven. You will work closely with researchers and clinical chemists at TU/e, Catharina Hospital and Máxima Medical Center, and with diagnostic and technology partners including Roche Diagnostics and SISCAPA Assay Technologies. You will also collaborate with PhD students and supervise Master and Bachelor students.

Expected impact
Your work will advance metrologically traceable and comparable protein biomarker measurements, support harmonization of tumor-marker testing across clinical laboratories, and establish methods that can be extended to biomarkers beyond lung cancer.

EngD in Digital Textile Manufacturing and Systems

Introduction
Are you inspired to make textile production digital, circular, and scalable for SMEs? Are you eager to turn machine, production, and ecosystem data into insights with data science, ML, and AI, working hands-on with real machines and their makers, to redesign complete textile value chains?

Job Description
Textile machines are often digital, but they are rarely connected or ready for data-driven work with machine learning and AI. Much of the production knowledge still lives in the heads and hands of operators. As a result, designers, producers, repairers and recyclers work in isolated steps, and valuable know-how and material are lost along the way. As an EngD trainee, you will help prepare textile production for the AI and ML age, and you will show how production and prototyping data can inform and redesign the complete value chain.

What you will do
You will design, build and adapt experimental machine setups with textile producers and machine builders, for example by adding sensors and controls or by linking machine settings to design files. You will use data science, machine learning and AI to turn machine, production and ecosystem data into insights that operators, designers and partners can use. Beyond machines, you will analyze how data-enabled production affects the wider ecosystem, from design and material choices to small-batch production, repair, reuse and recycling.

Working with people
This is a collaborative role. You will learn from operators and technicians, co-design with small companies, and turn fieldlab learning into workflows, demonstrators and open knowledge that others can build on. You will work in a public-private fieldlab with TU/e, industry, design researchers and the Dutch Textile Campus, with close supervision and room to grow as an engineer.

Why it matters
Your work helps Dutch textile SMEs meet new European circularity rules without losing their own craft, and keeps textiles and materials in use for longer. Moreover, the semiconductor industry in Eindhoven was built with engineering companies who made machinery for Textile companies. In this project we look to see how the knowledge generated informs all industries in the region.

Job Requirements

• A master’s degree (or an equivalent university degree) in Industrial Design or related field.
• A design-oriented attitude.
• Ability to work in a team and interest in collaborating with industrial partners.
• Fluent in spoken and written English.

Conditions of Employment
A meaningful job in a dynamic and ambitious university, in an interdisciplinary setting and within an international network. You will work on a beautiful, green campus within walking distance of the central train station.

In addition, we offer you:

• Full-time employment for two years.
• Salary in accordance with the Collective Labour Agreement for Dutch Universities, scale TOIO (€ 3.173 gross per month (full-time)).
• In addition to your base salary, you will receive an 8% holiday allowance and an 8.3% year-end bonus, both calculated based on your annual gross base salary.
• Generous leave options: a standard 29 days (based on a 38 hour working week) per year that you can increase to 41 days by working two hours more per week (flexible working hours). This is prorated if you work part-time.
• As a TU/e employee, you participate in the ABP pension scheme, providing retirement pension and pension benefits for surviving dependents and occupational disability. TU/e pays 70% of the pension premium, while employees contribute the remaining 30%.
• High-quality training programs on general skills, didactics and topics related to research and valorization.
• An excellent technical infrastructure, and on-campus children's day care.
• Unlimited access to the modern on‑campus TU/e Student Sports Center at an exceptionally affordable rate.
• We support your wellbeing with free 24/7 access to OpenUp, providing you and your family with mental health support, expert guidance, and online training.
• Partially paid parental leave and an allowance for commuting, working from home and internet costs.
• A TU/e Postdoc Association that helps you to build a stronger and broader academic and personal network, and offers tailored support, training and workshops.
• A Staff Immigration Team is available for international candidates, as are a tax compensation scheme (the Expat Scheme) and a compensation for moving expenses.

On our website you can discover even more information about our conditions of employment. Build on your career at TU/e!

About us
We are a leading international university where scientific curiosity meets a hands-on mindset. We work in an open and collaborative way with high-tech industries to tackle complex societal challenges. Our responsible and respectful approach ensures impact — today and in the future. TU/e is home to over 13,000 students and more than 7,000 staff, forming a diverse and vibrant academic community.

Our university is located in Brainport Eindhoven — a world‑leading tech region with more than 7,000 high‑tech companies and strong R&D activity. Known for breakthroughs in AI, photonics, semiconductors and advanced manufacturing, Brainport is a place where technology serves people and society. Learn more about the Brainport region here.

Information
Do you recognize yourself in this profile and would you like to know more? Please contact the hiring manager Troy Nachtigall, T.R.Nachtigall@tue.nl.

Visit our website for more information about the application process. You can also contact HRServices.ID@tue.nl.

Are you inspired and would like to know more about working at TU/e? Please visit our career page.

Application
We invite you to submit a complete application using the apply-button. The application should include a:

• A cover letter in which you describe your motivation and qualifications for the position.
• A curriculum vitae, including a list of your publications and the contact information of three references. Kindly note that we may reach out to references at any stage of the recruitment process. We recommend notifying your references upon submitting your application.
• Copies of relevant BSc and MSc diplomas and grade transcripts.
• The result of an English proficiency test such as IELTS or TOEFL.

Ensure that you submit all the requested application documents. Please note that incomplete applications may not be considered and could be rejected.

We look forward to receiving your application and will screen it as soon as possible. The vacancy will remain open until the position is filled.

Please note

• You can apply online. We will not process applications sent by email and/or post.
• A pre-employment screening (e.g. knowledge security check) can be part of the selection procedure. For more information on the knowledge security check, please consult the National Knowledge Security Guidelines.
• Please do not contact us for unsolicited services.

PhD on natural visual patterns, mental wellbeing, and overheating resilience

Introduction
Are you fascinated by the influence of nature on our emotions and behaviour? Passionate about nature-inspired facade design and its influence on occupant comfort and wellbeing? Eager to embark on a multidisciplinary research project and collaborate with industry partners? If so, then this PhD position might be perfect for you.

Job Description
Can we reduce stress, thermal discomfort and energy consumption for cooling in homes by harnessing visual exposure to nature-inspired facade designs? Can we disentangle the beneficial effects of daylight and nature exposure through windows? How can we best navigate the trade-off between access to view and the amount and quality of daylight and nature content provided by a nature-inspired façade? These are some of the scientific challenges you will work on in this PhD project.

This PhD position is part of the wider ΝWO KIC project “Nature4Homes: Nature-driven building skin interventions for energy efficiency, occupant comfort, health, and biodiversity in dwellings”, which brings together the domains of building engineering, building physics, environmental psychology, meteorology, and thermophysiology to develop nature-driven building skin solutions that enhance occupant health and comfort while reducing cooling demand. This PhD project focuses specifically on the domains of environmental psychology, lighting research, and building physics.

You will conduct your research within the Human-Technology Interaction group (HTI) at TU/e, which has a long history in lighting research and environmental psychology, with a secondment at the Environmental & Climate Design section at Delft University of Technology (TU Delft), which has extensive expertise in building physics and indoor environmental quality.

In this PhD, you will investigate whether visual patterns from nature across different layers of the building skin (e.g., the façade itself, the view to the outside) within an occupant’s field of view can support mental wellbeing, increase acceptance, and enhance tolerance to visual and thermal discomfort indoors, particularly during periods of summer overheating. To address these questions, you will review the literature, perform experiments in virtual reality and real conditions, co-create nature-inspired façade elements, and test them in field studies. Your work would include collecting self-reported, physiological, and environmental data, and apply building simulation, computer vision, and advanced statistical methods for their analysis. The project also involves close collaboration with industry partners such as shading system manufacturers to develop nature-inspired façade interventions. These will be tested at the “Green Village” living lab housing of TU Delft. Throughout your PhD, you will be supervised by Dr. Kynthia Chamilothori (main supervisor) and Prof. Yvonne de Kort (promotor) at the Human-Technology Interaction group of the Eindhoven University of Technology (TU/e), as well as Dr. Eleonora Brembilla (co-promotor) at the Environmental & Climate Design section at TU Delft. You will be based at TU/e with a secondment at TU Delft.

Job Requirements

• A master’s degree (or an equivalent university degree) in environmental psychology, lighting research, architectural or building engineering, or human-technology interaction.
• Proficiency in experimental research with human participants and quantitative data analysis, along with experience or eagerness to learn building simulation, façade technologies and programming.
• A research-oriented attitude.
• Ability to work in an interdisciplinary team and interest in collaborating with industrial partners.
• Motivated to develop your teaching skills and coach students.
• Fluent in spoken and written English (C1 level).

Conditions of Employment
A meaningful job in a dynamic and ambitious university, in an interdisciplinary setting and within an international network. You will work on a beautiful, green campus within walking distance of the central train station.

In addition, we offer you:

• Full-time employment for four years, with an intermediate assessment after nine months. You will spend a minimum of 10% of your four-year employment on teaching tasks, with a maximum of 15% per year of your employment.
• Salary and benefits (such as a pension scheme, paid pregnancy and maternity leave, partially paid parental leave) in accordance with the Collective Labour Agreement for Dutch Universities, scale P (min. € 3,204 - max. € 4,051 gross base salary per month (full-time)).
• In addition to your base salary, you will receive an 8% holiday allowance and an 8.3% year-end bonus, both calculated based on your annual gross base salary.
• Generous leave options: a standard 29 days (based on a 38 hour working week) per year that you can increase to 41 days by working two hours more per week (flexible working hours). This is prorated if you work part-time.
• As a TU/e employee, you participate in the ABP pension scheme, providing retirement pension and pension benefits for surviving dependents and occupational disability. TU/e pays 70% of the pension premium, while employees contribute the remaining 30%.
• High-quality training programs and other support to grow into a self-aware, autonomous scientific researcher. At TU/e we challenge you to take charge of your own learning process.
• An excellent technical infrastructure, and on-campus children's day care.
• Unlimited access to the modern on‑campus TU/e Student Sports Center at an exceptionally affordable rate.
• We support your wellbeing with free 24/7 access to OpenUp, providing you and your family with mental health support, expert guidance, and online training.
• An allowance for commuting, working from home and internet costs.
• A Staff Immigration Team and a tax compensation scheme (the Expat Scheme) for international candidates.

On our website you can discover even more information about our conditions of employment. Build on your career at TU/e!

About us
We are a leading international university where scientific curiosity meets a hands-on mindset. We work in an open and collaborative way with high-tech industries to tackle complex societal challenges. Our responsible and respectful approach ensures impact — today and in the future. TU/e is home to over 13,000 students and more than 7,000 staff, forming a diverse and vibrant academic community.

Our university is located in Brainport Eindhoven — a world‑leading tech region with more than 7,000 high‑tech companies and strong R&D activity. Known for breakthroughs in AI, photonics, semiconductors and advanced manufacturing, Brainport is a place where technology serves people and society. Learn more about the Brainport region here.

Information
Do you recognize yourself in this profile and would you like to know more? Please contact the hiring manager, Dr. Kynthia Chamilothori, at k.chamilothori@tue.nl.

Visit our website for more information about the application process. You can also contact HRServices.IEIS@tue.nl.

Curious to hear more about what it’s like as a PhD candidate at TU/e? Please view the video.

Are you inspired and would like to know more about working at TU/e? Please visit our career page.

Application
We invite you to submit a complete application by using the apply button. The application should include a:

• Cover letter in which you describe your motivation and qualifications for the position.
• Curriculum vitae, including a list of your publications and the contact information of three references. Kindly note that we may reach out to references at any stage of the recruitment process. We recommend notifying your references upon submitting your application.
• Brief description of your MSc thesis (topic, method, contribution) and other related research projects that you conducted.
• List of Master's and Bachelor’s courses, including grades.

Ensure that you submit all the requested application documents. We give priority to complete applications.

We look forward to receiving your application and will screen it as soon as possible. The vacancy will remain open until the position is filled.

Please note

• You can apply online. We will not process applications sent by email and/or post.
• A pre-employment screening (e.g. knowledge security check) can be part of the selection procedure. For more information on the knowledge security check, please consult the National Knowledge Security Guidelines.
• Please do not contact us for unsolicited services.

EngD in Digital Textile Manufacturing and Systems

Textile machines are often digital, but they are rarely connected or ready for data-driven work with machine learning and AI. Much of the production knowledge still lives in the heads and hands of operators. As a result, designers, producers, repairers and recyclers work in isolated steps, and valuable know-how and material are lost along the way. As an EngD trainee, you will help prepare textile production for the AI and ML age, and you will show how production and prototyping data can inform and redesign the complete value chain.

What you will do
You will design, build and adapt experimental machine setups with textile producers and machine builders, for example by adding sensors and controls or by linking machine settings to design files. You will use data science, machine learning and AI to turn machine, production and ecosystem data into insights that operators, designers and partners can use. Beyond machines, you will analyze how data-enabled production affects the wider ecosystem, from design and material choices to small-batch production, repair, reuse and recycling.

Working with people
This is a collaborative role. You will learn from operators and technicians, co-design with small companies, and turn fieldlab learning into workflows, demonstrators and open knowledge that others can build on. You will work in a public-private fieldlab with TU/e, industry, design researchers and the Dutch Textile Campus, with close supervision and room to grow as an engineer.

Why it matters
Your work helps Dutch textile SMEs meet new European circularity rules without losing their own craft, and keeps textiles and materials in use for longer. Moreover, the semiconductor industry in Eindhoven was built with engineering companies who made machinery for Textile companies. In this project we look to see how the knowledge generated informs all industries in the region.