PhD Position Monitoring and Control of Bench-scale CHO Cell Culture

Job description

In this PhD project you will working on developing and employing real-time monitoring and automated control of process flows in bench-scale CHO cell cultures for monoclonal antibody (mAb) production. You will be responsible for developing models to monitor key analytes in a biopharmaceutical process, including nutrients and product quality attributes. This means you will dive into process development for a standardized cell line and work on robust and transferable PAT monitoring models. Moreover, you will aim to use the real-time data to design strategies that allow you to (automatically) steer the process towards optimized productivity while maintaining product quality. This project includes wet lab (process development, data acquisition) and dry lab activities (spectroscopy-based model building, control).

Research group

The Klijn lab works on the implementation of real-time analytics in bioprocesses to faciliate automated monitoring and control strategies. We work on a broad range of processes, from microbial to mammalian, and we use a variety of process analytical techniques.

Job requirements
We are looking for an outstanding and creative researcher with a strong affinity to work at the boundary of multiple disciplines, namely bioprocessing engineering, multivariate data analysis, and automated control. This includes the internal motivation to expand your horizon, ablilty to learn quickly, and strong communication skills to easily connect with other experts in and outside the research group.

Required educational backgroud

• A MSc degree in biotechnology, bioprocess engineering, biochemical engineering, or a closely related discipline

We expect the candidate to have recent experience with:

• Running bioreactor-based mammalian cell culture processes (i.e., CHO, HEK, Vero)
• Using standard (bio)chemical analytical techniques (e.g., HPLC, bioanalyzer, cell counters)

This experience could be in the form of your current position, a MSc thesis project, or a MSc internship.

Skills that are considered a big plus:

• Programming for data analysis and/or modelling of bioprocesses (e.g., R, Python, Matlab)
• Multivariate data analysis, chemometrics, and/or machine learning

Sought-after transferable skills

• Pro-active and problem solving mindset
• Excellent written and spoken English skills
• Ability to break-down and communicate complex research data
• Thrives in a fast-paced, multidisciplinary, and highly collaborative environment

TU Delft (Delft University of Technology)
Delft University of Technology is built on strong foundations. As creators of the world-famous Dutch waterworks and pioneers in biotech, TU Delft is a top international university combining science, engineering and design. It delivers world class results in education, research and innovation to address challenges in the areas of energy, climate, mobility, health and digital society. For generations, our engineers have proven to be entrepreneurial problem-solvers, both in business and in a social context.

At TU Delft we embrace diversity as one of our core values and we actively engage to be a university where you feel at home and can flourish. We value different perspectives and qualities. We believe this makes our work more innovative, the TU Delft community more vibrant and the world more just. Together, we imagine, invent and create solutions using technology to have a positive impact on a global scale. That is why we invite you to apply. Your application will receive fair consideration.

Challenge. Change. Impact!

Faculty Applied Sciences
With more than 1,100 employees, including 150 pioneering principal investigators, as well as a population of about 3,600 passionate students, the Faculty of Applied Sciences is an inspiring scientific ecosystem. Focusing on key enabling technologies, such as quantum- and nanotechnology, photonics, biotechnology, synthetic biology and materials for energy storage and conversion, our faculty aims to provide solutions to important problems of the 21st century. To that end, we educate innovative students in broad Bachelor's and specialist Master's programmes with a strong research component. Our scientists conduct ground-breaking fundamental and applied research in the fields of Life and Health Science & Technology, Nanoscience, Chemical Engineering, Radiation Science & Technology, and Engineering Physics. We are also training the next generation of high school teachers.

Click here to go to the website of the Faculty of Applied Sciences.

Postdoc Electro-Mechanical Sensing in Organs-on-Chip

Job description

Organ-on-Chip (OoC) systems are microfluidic cell culture devices that recapitulate in-vivo-like microenvironments to allow the realistic expression of the functions of human tissues and organs in-vitro. Such microphysiological systems are more representative models than existing in-vitro cell cultures, and aim to enhance pre-clinical screening of the effect of drugs and other compounds on the human body.

The 4-year "Phoenix" project targets specifically the development of an advanced OoC platform capable of electrical recording and mechanical stimulation of cardiac and neuro-muscular tissues, as well as sensing of their contractile force. This ambitious goal will be achieved through an incremental and carefully-structured workplan and the fertile collaboration of multiple expert international partners, both academic and industrial, bio-technological and clinical. In this stimulating and inspiring context, you will experience the opportunity to be active in a truly multi-disciplinary research initiative. You will contribute with innovative ideas and solutions for the integration in an existing OoC platform of micro-electro-mechanical sensors for accurate quantification of contractile force from cardiac and neuromuscular tissues. The research will involve materials selection for compatibility and functionality, conception and design of the sensing system, its modelling and microfabrication, as well as characterization and testing of the proposed solutions before biological validation.

Electronic Components, Technology and Materials (ECTM)
Be a part of a leading research team with great track record in micro/nanotechnology. You’ll be working at the Electronic Components, Technology and Materials (ECTM) section of the Department of Microelectronics from Faculty EEMCS under supervision of Dr. Massimo Mastrangeli. At ECTM, you will be joining a dynamic and supportive research environment, home to a highly-motivated international team of professors and a growing group of postdocs, PhD and Master students. We offer access to state-of-the-art equipment and facilities, including advanced laboratories and cutting-edge tools to support your research. At ECTM, you'll find an open and friendly environment, with opportunities for professional development and training to successfully develop your academic skills. We do not distinguish between hierarchical levels, and we have a strong collaborative culture. We interact on a daily basis and share a drive to strengthen the position of the group as a whole thanks to the growth of each member.

Job requirements
You need to have:

• a Doctoral degree in Microelectronics, Microelectromechanical Systems (MEMS), Microfabrication, Biomedical Engineering, Materials Science or related fields;
• strong experience in micro/nanofabrication, materials engineering and electrical engineering;
• a self-driven attitude, creativity and autonomy;
• facility and ease in working in a multi-disciplinary and challenging context;
• Strong written and oral communication skills in English.

The following will make you stand out: Perseverance, ambition, proactivity, collaborative attitude.

TU Delft (Delft University of Technology)
Delft University of Technology is built on strong foundations. As creators of the world-famous Dutch waterworks and pioneers in biotech, TU Delft is a top international university combining science, engineering and design. It delivers world class results in education, research and innovation to address challenges in the areas of energy, climate, mobility, health and digital society. For generations, our engineers have proven to be entrepreneurial problem-solvers, both in business and in a social context.

At TU Delft we embrace diversity as one of our core values and we actively engage to be a university where you feel at home and can flourish. We value different perspectives and qualities. We believe this makes our work more innovative, the TU Delft community more vibrant and the world more just. Together, we imagine, invent and create solutions using technology to have a positive impact on a global scale. That is why we invite you to apply. Your application will receive fair consideration.

Challenge. Change. Impact!

Faculty of Electrical Engineering, Mathematics and Computer Science
The Faculty of Electrical Engineering, Mathematics and Computer Science (EEMCS) brings together three scientific disciplines. Combined, they reinforce each other and are the driving force behind the technology we all use in our daily lives. Technology such as the electricity grid, which our faculty is helping to make completely sustainable and future-proof. At the same time, we are developing the chips and sensors of the future, whilst also setting the foundations for the software technologies to run on this new generation of equipment – which of course includes AI. Meanwhile we are pushing the limits of applied mathematics, for example mapping out disease processes using single cell data, and using mathematics to simulate gigantic ash plumes after a volcanic eruption. In other words: there is plenty of room at the faculty for ground-breaking research. We educate innovative engineers and have excellent labs and facilities that underline our strong international position. In total, more than 1000 employees and 4,000 students work and study in this innovative environment.

Click here to go to the website of the Faculty of Electrical Engineering, Mathematics and Computer Science.

PhD Position Monitoring and Control of Bench-scale CHO Cell Culture

Job description

In this PhD project you will working on developing and employing real-time monitoring and automated control of process flows in bench-scale CHO cell cultures for monoclonal antibody (mAb) production. You will be responsible for developing models to monitor key analytes in a biopharmaceutical process, including nutrients and product quality attributes. This means you will dive into process development for a standardized cell line and work on robust and transferable PAT monitoring models. Moreover, you will aim to use the real-time data to design strategies that allow you to (automatically) steer the process towards optimized productivity while maintaining product quality. This project includes wet lab (process development, data acquisition) and dry lab activities (spectroscopy-based model building, control).

Research group

The Klijn lab works on the implementation of real-time analytics in bioprocesses to faciliate automated monitoring and control strategies. We work on a broad range of processes, from microbial to mammalian, and we use a variety of process analytical techniques.

Job requirements
We are looking for an outstanding and creative researcher with a strong affinity to work at the boundary of multiple disciplines, namely bioprocessing engineering, multivariate data analysis, and automated control. This includes the internal motivation to expand your horizon, ablilty to learn quickly, and strong communication skills to easily connect with other experts in and outside the research group.

Required educational backgroud

• A MSc degree in biotechnology, bioprocess engineering, biochemical engineering, or a closely related discipline

We expect the candidate to have recent experience with:

• Running bioreactor-based mammalian cell culture processes (i.e., CHO, HEK, Vero)
• Using standard (bio)chemical analytical techniques (e.g., HPLC, bioanalyzer, cell counters)

This experience could be in the form of your current position, a MSc thesis project, or a MSc internship.

Skills that are considered a big plus:

• Programming for data analysis and/or modelling of bioprocesses (e.g., R, Python, Matlab)
• Multivariate data analysis, chemometrics, and/or machine learning

Sought-after transferable skills

• Pro-active and problem solving mindset
• Excellent written and spoken English skills
• Ability to break-down and communicate complex research data
• Thrives in a fast-paced, multidisciplinary, and highly collaborative environment

TU Delft (Delft University of Technology)
Delft University of Technology is built on strong foundations. As creators of the world-famous Dutch waterworks and pioneers in biotech, TU Delft is a top international university combining science, engineering and design. It delivers world class results in education, research and innovation to address challenges in the areas of energy, climate, mobility, health and digital society. For generations, our engineers have proven to be entrepreneurial problem-solvers, both in business and in a social context.

At TU Delft we embrace diversity as one of our core values and we actively engage to be a university where you feel at home and can flourish. We value different perspectives and qualities. We believe this makes our work more innovative, the TU Delft community more vibrant and the world more just. Together, we imagine, invent and create solutions using technology to have a positive impact on a global scale. That is why we invite you to apply. Your application will receive fair consideration.

Challenge. Change. Impact!

Faculty Applied Sciences
With more than 1,100 employees, including 150 pioneering principal investigators, as well as a population of about 3,600 passionate students, the Faculty of Applied Sciences is an inspiring scientific ecosystem. Focusing on key enabling technologies, such as quantum- and nanotechnology, photonics, biotechnology, synthetic biology and materials for energy storage and conversion, our faculty aims to provide solutions to important problems of the 21st century. To that end, we educate innovative students in broad Bachelor's and specialist Master's programmes with a strong research component. Our scientists conduct ground-breaking fundamental and applied research in the fields of Life and Health Science & Technology, Nanoscience, Chemical Engineering, Radiation Science & Technology, and Engineering Physics. We are also training the next generation of high school teachers.

Click here to go to the website of the Faculty of Applied Sciences.

Postdoc Electro-Mechanical Sensing in Organs-on-Chip

Job description

Organ-on-Chip (OoC) systems are microfluidic cell culture devices that recapitulate in-vivo-like microenvironments to allow the realistic expression of the functions of human tissues and organs in-vitro. Such microphysiological systems are more representative models than existing in-vitro cell cultures, and aim to enhance pre-clinical screening of the effect of drugs and other compounds on the human body.

The 4-year "Phoenix" project targets specifically the development of an advanced OoC platform capable of electrical recording and mechanical stimulation of cardiac and neuro-muscular tissues, as well as sensing of their contractile force. This ambitious goal will be achieved through an incremental and carefully-structured workplan and the fertile collaboration of multiple expert international partners, both academic and industrial, bio-technological and clinical. In this stimulating and inspiring context, you will experience the opportunity to be active in a truly multi-disciplinary research initiative. You will contribute with innovative ideas and solutions for the integration in an existing OoC platform of micro-electro-mechanical sensors for accurate quantification of contractile force from cardiac and neuromuscular tissues. The research will involve materials selection for compatibility and functionality, conception and design of the sensing system, its modelling and microfabrication, as well as characterization and testing of the proposed solutions before biological validation.

Electronic Components, Technology and Materials (ECTM)
Be a part of a leading research team with great track record in micro/nanotechnology. You’ll be working at the Electronic Components, Technology and Materials (ECTM) section of the Department of Microelectronics from Faculty EEMCS under supervision of Dr. Massimo Mastrangeli. At ECTM, you will be joining a dynamic and supportive research environment, home to a highly-motivated international team of professors and a growing group of postdocs, PhD and Master students. We offer access to state-of-the-art equipment and facilities, including advanced laboratories and cutting-edge tools to support your research. At ECTM, you'll find an open and friendly environment, with opportunities for professional development and training to successfully develop your academic skills. We do not distinguish between hierarchical levels, and we have a strong collaborative culture. We interact on a daily basis and share a drive to strengthen the position of the group as a whole thanks to the growth of each member.

Job requirements
You need to have:

• a Doctoral degree in Microelectronics, Microelectromechanical Systems (MEMS), Microfabrication, Biomedical Engineering, Materials Science or related fields;
• strong experience in micro/nanofabrication, materials engineering and electrical engineering;
• a self-driven attitude, creativity and autonomy;
• facility and ease in working in a multi-disciplinary and challenging context;
• Strong written and oral communication skills in English.

The following will make you stand out: Perseverance, ambition, proactivity, collaborative attitude.

TU Delft (Delft University of Technology)
Delft University of Technology is built on strong foundations. As creators of the world-famous Dutch waterworks and pioneers in biotech, TU Delft is a top international university combining science, engineering and design. It delivers world class results in education, research and innovation to address challenges in the areas of energy, climate, mobility, health and digital society. For generations, our engineers have proven to be entrepreneurial problem-solvers, both in business and in a social context.

At TU Delft we embrace diversity as one of our core values and we actively engage to be a university where you feel at home and can flourish. We value different perspectives and qualities. We believe this makes our work more innovative, the TU Delft community more vibrant and the world more just. Together, we imagine, invent and create solutions using technology to have a positive impact on a global scale. That is why we invite you to apply. Your application will receive fair consideration.

Challenge. Change. Impact!

Faculty of Electrical Engineering, Mathematics and Computer Science
The Faculty of Electrical Engineering, Mathematics and Computer Science (EEMCS) brings together three scientific disciplines. Combined, they reinforce each other and are the driving force behind the technology we all use in our daily lives. Technology such as the electricity grid, which our faculty is helping to make completely sustainable and future-proof. At the same time, we are developing the chips and sensors of the future, whilst also setting the foundations for the software technologies to run on this new generation of equipment – which of course includes AI. Meanwhile we are pushing the limits of applied mathematics, for example mapping out disease processes using single cell data, and using mathematics to simulate gigantic ash plumes after a volcanic eruption. In other words: there is plenty of room at the faculty for ground-breaking research. We educate innovative engineers and have excellent labs and facilities that underline our strong international position. In total, more than 1000 employees and 4,000 students work and study in this innovative environment.

Click here to go to the website of the Faculty of Electrical Engineering, Mathematics and Computer Science.

Senior Strategy and Policy Advisor

Job description
Quantum Internet Alliance (QIA)’s mission is to build a global Quantum Internet by developing a full stack prototype quantum internet network that validates all key subsystems. As a pioneering community dedicated to advancing a groundbreaking technology, QIA combines world-class research with ecosystem building and policy engagement to position Europe at the forefront of quantum networking. QIA’s ambition extends beyond scientific leadership. The aim is to build an innovative European Quantum Internet ecosystem, capable of scaling all sub-systems to achieve world-leading European technology. In this regard QIA has launched the world’s first global quantum internet technology forum (QIATF) and is expanding its ecosystem further. Find out more about QIA at https://quantuminternetalliance.org/.

As Senior Strategy & Policy Advisor, you will play a central strategic advisory role, working closely with the QIA Director and senior decision-makers to shape and advance QIA’s long-term vision for the quantum internet in Europe. The role sits at the intersection of quantum R&D, European industrial and digital policy, economic security, and ecosystem development, with a clear mandate to translate Europe’s technological leadership into economic competitiveness, digital sovereignty, and global influence. As the Advisor, you will support the delivery of a “Global Quantum Internet Made in Europe” by aligning QIA’s Quantum Internet Initiative (QI²) with broader EU strategic frameworks such as the Digital Decade, industrial policy, open strategic autonomy, and relevant defence and security dimensions, while leading high-level policy engagement, anticipating future funding and programme developments, and positioning QIA as a recognised strategic actor with external visibility within the evolving European and global quantum ecosystem. In this role, you will work with a high degree of autonomy and influence, in close proximity to the QIA Director, senior governance structures, and external decision-makers, shaping European quantum internet strategy at senior political, institutional, and ecosystem levels.

IMPORTANT: In this role, you will need to be in Brussels at the EU Commission for most of your work. Therefore, living close to Brussels is preferred. You can come to QuTech once a week or every two weeks.

Key Responsibilities

• Act as a strategic advisor to the QIA Director, providing policy analysis and strategic advice on QI² positioning, priorities, and long-term direction.
• Support and shape high-level engagement with political, institutional, and funding stakeholders at national, European, and international levels, including EU institutions, Member States, and international partners.
• Prepare executive-level strategic plans, policy papers, and briefing materials to inform internal decision-making and support senior-level external engagement.
• Position QIA/QI² within the broader European policy landscape, advising on policies that support European quantum internet leadership across the value chain, with particular focus on software, platforms, open infrastructures, and standardisation.
• Contribute to ecosystem and industry engagement strategies, including interaction with industry players, scale-ups, infrastructure providers, and standardisation bodies, to help translate R&D leadership into market uptake and economic impact.
• Monitor, analyse, and anticipate EU and national funding and programme developments (e.g. Horizon Europe, Digital Europe, defence-related instruments, future FP10), and support proactive positioning and influence for future calls and initiatives, beyond the management of current programmes.
• Work closely with innovation and technical teams to strategically translate between technology developments and policy priorities, ensuring coherence between research, ecosystem building, and policy positioning (without responsibility for technical oversight).
• Act as a key liaison between QIA/QI² and the wider policy and governance ecosystem, preparing briefings and follow-up actions for senior-level meetings

Qualifications

• Master’s degree (or equivalent) in Public Policy, Political Science, International Relations, Management, or a related field.
• At least 6 years of experience in senior strategic policy advisory, programme coordination, or strategic project management roles within research, innovation, or policy-driven environments.
• Proven experience with EU and/or national public funding instruments and programmes, including Horizon Europe and related initiatives; experience with EU-funded projects is a requirement.
• Strong understanding of European policy-making processes, institutional dynamics, and governance frameworks, with the ability to operate credibly at senior political and institutional levels.
• Experience working in large-scale, multi-actor, multidisciplinary R&D or innovation initiatives.
• Demonstrated ability to operate independently and with discretion, managing sensitive information and providing trusted advice at senior level. • Excellent stakeholder engagement, networking, and relationship-building skills, including interaction with political, governmental, or funding institutions.
• Strong organisational and coordination skills, with the ability to connect technology, policy, industry, and innovation perspectives.
• Sufficient technical understanding of deep-tech and digital infrastructure domains (e.g. quantum technologies, advanced communications) to engage credibly with technical leaders, while maintaining a primary focus on strategic translation between technology and policy rather than technical execution.
• Excellent written and verbal communication skills in English; proficiency in Dutch is a strong plus.

TU Delft
Delft University of Technology is built on strong foundations. As creators of the world-famous Dutch waterworks and pioneers in biotech, TU Delft is a top international university combining science, engineering and design. It delivers world class results in education, research and innovation to address challenges in the areas of energy, climate, mobility, health and digital society. For generations, our engineers have proven to be entrepreneurial problem-solvers, both in business and in a social context.

At TU Delft we embrace diversity as one of our core values and we actively engage to be a university where you feel at home and can flourish. We value different perspectives and qualities. We believe this makes our work more innovative, the TU Delft community more vibrant and the world more just. Together, we imagine, invent and create solutions using technology to have a positive impact on a global scale. That is why we invite you to apply. Your application will receive fair consideration.

Challenge. Change. Impact!

QuTech
QuTech is a mission-driven research institute of TU Delft. Together we are working on a radical new technology with world-changing potential. We are developing scalable prototypes of a quantum computer and a secure quantum internet.

We believe quantum technology will be a game changer in many social and economic sectors - including health, agriculture, climate, and security. To achieve our ambitious goals, we bring scientists, engineers, and industry together in an inspiring environment, with plenty of room for ambition, entrepreneurship, and innovation.

Have a look at our video and get a glimpse of QuTech.