PhD Position in Single-Molecule Biophysic

Job description

We are looking for a PhD student passionate about understanding molecular mechanisms in biological systems. This position involves applying single-molecule techniques to study molecular interactions, including protein-ligand interactions and protein-peptide interactions. The candidate will work in an interdisciplinary environment, combining experimental approaches (single molecule fluorescence and biochemistry) with computational methods. The candidate will obtain single-molecule multiplexing data and validate machine learning predictions using the high-throughput data. The successful candidate will collaborate with international partners for therapeutic applications of this research. The project offers opportunities to make significant contributions to understanding molecular interactions and their implications for both fundamental and medical sciences.

Job requirements

• MSc degree (or nearing completion) in physics, biophysics, computational biology, or a related field.
• Strong programming skills (Python) and experience in data analysis and computational methods.
• Familiarity with molecular biology techniques.
• Excellent written and spoken English skills.
• Ability to work effectively in a collaborative, international, and interdisciplinary environment.

TU Delft (Delft University of Technology)
Delft University of Technology is built on strong foundations. As creators of the world-famous Dutch waterworks and pioneers in biotech, TU Delft is a top international university combining science, engineering and design. It delivers world class results in education, research and innovation to address challenges in the areas of energy, climate, mobility, health and digital society. For generations, our engineers have proven to be entrepreneurial problem-solvers, both in business and in a social context.

At TU Delft we embrace diversity as one of our core values and we actively engage to be a university where you feel at home and can flourish. We value different perspectives and qualities. We believe this makes our work more innovative, the TU Delft community more vibrant and the world more just. Together, we imagine, invent and create solutions using technology to have a positive impact on a global scale. That is why we invite you to apply. Your application will receive fair consideration.

Challenge. Change. Impact!

Faculty Applied Sciences
With more than 1,100 employees, including 150 pioneering principal investigators, as well as a population of about 3,600 passionate students, the Faculty of Applied Sciences is an inspiring scientific ecosystem. Focusing on key enabling technologies, such as quantum- and nanotechnology, photonics, biotechnology, synthetic biology and materials for energy storage and conversion, our faculty aims to provide solutions to important problems of the 21st century. To that end, we educate innovative students in broad Bachelor's and specialist Master's programmes with a strong research component. Our scientists conduct ground-breaking fundamental and applied research in the fields of Life and Health Science & Technology, Nanoscience, Chemical Engineering, Radiation Science & Technology, and Engineering Physics. We are also training the next generation of high school teachers.

Click here to go to the website of the Faculty of Applied Sciences.

Postdoc Physics of Cellular Robustness

Job description

Cells display a remarkable ability to adapt to strong genetic perturbations. In some cases, only a handful of mutations are sufficient to restore cellular function, even after major disruptions. This raises a fundamental question: how do cells reorganize their internal processes to buffer such perturbations and maintain functionality?

Within the ERC Consolidator Grant project PolarRobustness, we investigate the idea that cellular processes are not independent, but physically coupled. These couplings may allow processes to absorb and compensate for disturbances in each other, giving rise to a collective form of robustness. Understanding this requires moving beyond studying a single process in isolation, and instead capturing how multiple processes interact dynamically within the same cell.

In this postdoctoral project, you will in collaboration develop and apply an integrated experimental and theoretical framework to study multiple coupled cellular processes simultaneously. You will combine advanced live-cell microscopy with inference-based modeling to quantitatively describe how cells coordinate key processes over time.

You will work closely with an interdisciplinary team to establish a systems-level understanding of how coupled cellular processes collectively buffer perturbations.

Job requirements
The project will start in September and is embedded in the Laan Lab at the Department of Bionanoscience, Faculty of Applied Sciences, TU Delft. The lab offers a highly collaborative and international environment at the interface of physics and biology.

We are looking for a candidate with strong experience in live-cell microscopy and a keen interest in combining experiments with quantitative modeling to uncover fundamental principles of cellular organization and robustness. We expect the candidate to be a team-player, to have an independent and well-organized work style, to be communicative and creative, and to contribute to our open, interactive, and social lab culture.

TU Delft (Delft University of Technology)
Delft University of Technology is built on strong foundations. As creators of the world-famous Dutch waterworks and pioneers in biotech, TU Delft is a top international university combining science, engineering and design. It delivers world class results in education, research and innovation to address challenges in the areas of energy, climate, mobility, health and digital society. For generations, our engineers have proven to be entrepreneurial problem-solvers, both in business and in a social context.

At TU Delft we embrace diversity as one of our core values and we actively engage to be a university where you feel at home and can flourish. We value different perspectives and qualities. We believe this makes our work more innovative, the TU Delft community more vibrant and the world more just. Together, we imagine, invent and create solutions using technology to have a positive impact on a global scale. That is why we invite you to apply. Your application will receive fair consideration.

Challenge. Change. Impact!

Faculty Applied Sciences
With more than 1,100 employees, including 150 pioneering principal investigators, as well as a population of about 3,600 passionate students, the Faculty of Applied Sciences is an inspiring scientific ecosystem. Focusing on key enabling technologies, such as quantum- and nanotechnology, photonics, biotechnology, synthetic biology and materials for energy storage and conversion, our faculty aims to provide solutions to important problems of the 21st century. To that end, we educate innovative students in broad Bachelor's and specialist Master's programmes with a strong research component. Our scientists conduct ground-breaking fundamental and applied research in the fields of Life and Health Science & Technology, Nanoscience, Chemical Engineering, Radiation Science & Technology, and Engineering Physics. We are also training the next generation of high school teachers.

Click here to go to the website of the Faculty of Applied Sciences.

PhD Position in Single-Molecule Biophysic

Job description

We are looking for a PhD student passionate about understanding molecular mechanisms in biological systems. This position involves applying single-molecule techniques to study molecular interactions, including protein-ligand interactions and protein-peptide interactions. The candidate will work in an interdisciplinary environment, combining experimental approaches (single molecule fluorescence and biochemistry) with computational methods. The candidate will obtain single-molecule multiplexing data and validate machine learning predictions using the high-throughput data. The successful candidate will collaborate with international partners for therapeutic applications of this research. The project offers opportunities to make significant contributions to understanding molecular interactions and their implications for both fundamental and medical sciences.

Job requirements

• MSc degree (or nearing completion) in physics, biophysics, computational biology, or a related field.
• Strong programming skills (Python) and experience in data analysis and computational methods.
• Familiarity with molecular biology techniques.
• Excellent written and spoken English skills.
• Ability to work effectively in a collaborative, international, and interdisciplinary environment.

TU Delft (Delft University of Technology)
Delft University of Technology is built on strong foundations. As creators of the world-famous Dutch waterworks and pioneers in biotech, TU Delft is a top international university combining science, engineering and design. It delivers world class results in education, research and innovation to address challenges in the areas of energy, climate, mobility, health and digital society. For generations, our engineers have proven to be entrepreneurial problem-solvers, both in business and in a social context.

At TU Delft we embrace diversity as one of our core values and we actively engage to be a university where you feel at home and can flourish. We value different perspectives and qualities. We believe this makes our work more innovative, the TU Delft community more vibrant and the world more just. Together, we imagine, invent and create solutions using technology to have a positive impact on a global scale. That is why we invite you to apply. Your application will receive fair consideration.

Challenge. Change. Impact!

Faculty Applied Sciences
With more than 1,100 employees, including 150 pioneering principal investigators, as well as a population of about 3,600 passionate students, the Faculty of Applied Sciences is an inspiring scientific ecosystem. Focusing on key enabling technologies, such as quantum- and nanotechnology, photonics, biotechnology, synthetic biology and materials for energy storage and conversion, our faculty aims to provide solutions to important problems of the 21st century. To that end, we educate innovative students in broad Bachelor's and specialist Master's programmes with a strong research component. Our scientists conduct ground-breaking fundamental and applied research in the fields of Life and Health Science & Technology, Nanoscience, Chemical Engineering, Radiation Science & Technology, and Engineering Physics. We are also training the next generation of high school teachers.

Click here to go to the website of the Faculty of Applied Sciences.

Postdoc Physics of Cellular Robustness

Job description

Cells display a remarkable ability to adapt to strong genetic perturbations. In some cases, only a handful of mutations are sufficient to restore cellular function, even after major disruptions. This raises a fundamental question: how do cells reorganize their internal processes to buffer such perturbations and maintain functionality?

Within the ERC Consolidator Grant project PolarRobustness, we investigate the idea that cellular processes are not independent, but physically coupled. These couplings may allow processes to absorb and compensate for disturbances in each other, giving rise to a collective form of robustness. Understanding this requires moving beyond studying a single process in isolation, and instead capturing how multiple processes interact dynamically within the same cell.

In this postdoctoral project, you will in collaboration develop and apply an integrated experimental and theoretical framework to study multiple coupled cellular processes simultaneously. You will combine advanced live-cell microscopy with inference-based modeling to quantitatively describe how cells coordinate key processes over time.

You will work closely with an interdisciplinary team to establish a systems-level understanding of how coupled cellular processes collectively buffer perturbations.

Job requirements
The project will start in September and is embedded in the Laan Lab at the Department of Bionanoscience, Faculty of Applied Sciences, TU Delft. The lab offers a highly collaborative and international environment at the interface of physics and biology.

We are looking for a candidate with strong experience in live-cell microscopy and a keen interest in combining experiments with quantitative modeling to uncover fundamental principles of cellular organization and robustness. We expect the candidate to be a team-player, to have an independent and well-organized work style, to be communicative and creative, and to contribute to our open, interactive, and social lab culture.

TU Delft (Delft University of Technology)
Delft University of Technology is built on strong foundations. As creators of the world-famous Dutch waterworks and pioneers in biotech, TU Delft is a top international university combining science, engineering and design. It delivers world class results in education, research and innovation to address challenges in the areas of energy, climate, mobility, health and digital society. For generations, our engineers have proven to be entrepreneurial problem-solvers, both in business and in a social context.

At TU Delft we embrace diversity as one of our core values and we actively engage to be a university where you feel at home and can flourish. We value different perspectives and qualities. We believe this makes our work more innovative, the TU Delft community more vibrant and the world more just. Together, we imagine, invent and create solutions using technology to have a positive impact on a global scale. That is why we invite you to apply. Your application will receive fair consideration.

Challenge. Change. Impact!

Faculty Applied Sciences
With more than 1,100 employees, including 150 pioneering principal investigators, as well as a population of about 3,600 passionate students, the Faculty of Applied Sciences is an inspiring scientific ecosystem. Focusing on key enabling technologies, such as quantum- and nanotechnology, photonics, biotechnology, synthetic biology and materials for energy storage and conversion, our faculty aims to provide solutions to important problems of the 21st century. To that end, we educate innovative students in broad Bachelor's and specialist Master's programmes with a strong research component. Our scientists conduct ground-breaking fundamental and applied research in the fields of Life and Health Science & Technology, Nanoscience, Chemical Engineering, Radiation Science & Technology, and Engineering Physics. We are also training the next generation of high school teachers.

Click here to go to the website of the Faculty of Applied Sciences.

PhD Position Rethinking Electrical Engineering Education in the Age of AI

Job description

AI is changing what it means to be an electrical engineer — and we think that's an exciting research questions out there right now. At TU Delft's Electrical Engineering Education (EEE) section, we're looking for a PhD researcher to dig into something that really matters: as AI tools become capable of coding, designing circuits, and processing signals, what should students actually learn, and how do we know when they've learned it?

This isn't just a theoretical exercise. AI is already reshaping engineering practice at speed — and that raises urgent questions about which competencies remain essential for critical judgement, systems thinking, and responsible decision-making, and which can be meaningfully supported by AI. Your research will help us figure out where that line is, and what it means for how we teach.

As part of our team, you'll take a fresh look at EE curricula — not just what students learn, but how they learn and how we assess their growth. A central aim of the project is to move beyond grading final outputs and start understanding what's happening in between: the reasoning, the decision-making, the creative instincts students bring when working with AI. We want to know how students think, not just what they produce.

The research is grounded in a critical thinking perspective and explores how AI shifts the balance between theory, practice, and the genuinely creative parts of engineering — design, system development, problem framing. You'll be working in our hands-on educational environments at TU Delft: labs, makerspaces, project-based courses, and real electrical engineering classrooms. You'll investigate how students interact with AI tools, how that shapes their learning behaviours and sense of agency, and how they position their own contributions relative to what the AI generates.

Methodologically, you'll combine design-based research, learning analytics, and qualitative methods to develop and test new approaches to learning and assessment — formats that make students' reasoning visible, that encourage critical engagement with AI-generated solutions, and that support reflective, responsible use of AI.

In practice, this means you'll be investigating AI use in EE learning environments, examining its impact on what competencies matter, designing and running new assessment approaches, and developing ways to evaluate students' reasoning beyond the final answer. You'll work closely with teaching staff and contribute to academic publications throughout.

What you'll help us build: new insights into how AI reshapes competencies and student agency in EE education, a clearer picture of which skills are essential versus AI-supported, and practical frameworks that align learning objectives, AI use, and assessment. Your work will shape the future of EE education at TU Delft — and contribute to leading venues in engineering education and the learning sciences.

If you're curious about education, excited by the possibilities (and the risks) of AI in engineering, and want your research to have real impact on how the next generation of engineers is trained — we'd love to have you with us.

Job requirements
You have:

• A Bachelors degree in engineering, education, learning sciences, or a related field.
• A Master’s degree in engineering, education, learning sciences, or a related field.
• A strong interest in electrical engineering education, learning processes, and the role of AI in education.
• Affinity with both technical and educational research (e.g., AI, data analysis, or learning sciences).
• Experience with qualitative and/or quantitative research methods.
• Strong analytical, communication, and collaboration skills.
• Excellent command of English.

TU Delft (Delft University of Technology)
Delft University of Technology is built on strong foundations. As creators of the world-famous Dutch waterworks and pioneers in biotech, TU Delft is a top international university combining science, engineering and design. It delivers world class results in education, research and innovation to address challenges in the areas of energy, climate, mobility, health and digital society. For generations, our engineers have proven to be entrepreneurial problem-solvers, both in business and in a social context.

At TU Delft we embrace diversity as one of our core values and we actively engage to be a university where you feel at home and can flourish. We value different perspectives and qualities. We believe this makes our work more innovative, the TU Delft community more vibrant and the world more just. Together, we imagine, invent and create solutions using technology to have a positive impact on a global scale. That is why we invite you to apply. Your application will receive fair consideration.

Challenge. Change. Impact!

Faculty of Electrical Engineering, Mathematics and Computer Science
The Faculty of Electrical Engineering, Mathematics and Computer Science (EEMCS) brings together three scientific disciplines. Combined, they reinforce each other and are the driving force behind the technology we all use in our daily lives. Technology such as the electricity grid, which our faculty is helping to make completely sustainable and future-proof. At the same time, we are developing the chips and sensors of the future, whilst also setting the foundations for the software technologies to run on this new generation of equipment – which of course includes AI. Meanwhile we are pushing the limits of applied mathematics, for example mapping out disease processes using single cell data, and using mathematics to simulate gigantic ash plumes after a volcanic eruption. In other words: there is plenty of room at the faculty for ground-breaking research. We educate innovative engineers and have excellent labs and facilities that underline our strong international position. In total, more than 1000 employees and 4,000 students work and study in this innovative environment.

Click here to go to the website of the Faculty of Electrical Engineering, Mathematics and Computer Science.