Postdoc position - Unraveling Immune Checkpoint Inhibitor Toxicity and Efficacy

Immune checkpoint inhibitors (ICIs) have been the largest breakthrough in oncology in the last decade. However, they are effective for only a minority of patients and can cause severe immune-mediated toxicities. Within the UNICIT biobank, we have collected sequential blood, feces, and tissue biopsy samples from more than 600 patients treated with ICIs. This unique resource allows you to investigate the mechanisms behind ICI toxicity and treatment resistance and identify factors that could improve patient outcomes.

As a postdoctoral researcher, you will join the research group of Prof. Karijn Suijkerbuijk at the Department of Medical Oncology. The group focuses on clinical and translational research in melanoma and cancer immunotherapy, with a strong emphasis on immune checkpoint inhibitors.

You will conduct a research project on ICI toxicity and resistance under the supervision of Prof. Karijn Suijkerbuijk. Alongside your own research, you will contribute to collaborative projects, supervise junior researchers and PhD candidates, and help develop new research proposals to secure future funding.

Key responsibilities
As a postdoctoral researcher, you will:

• Plan, perform, and document experiments.
• Analyze and interpret molecular and clinical data.
• Present your findings in oral and written presentations.
• Collaborate closely with researchers within and outside the department.
• Supervise junior researchers and/or PhD candidates working on related projects.
• Write grant proposals.

ICT Support Technician - Imaging Physics

Job description

The Department of Imaging Physics at Delft University of Technology develops advanced imaging systems that contribute to scientific and societal impact. Research within the department focuses on innovative instrumentation, data processing and algorithm development for imaging applications.

As an ICT Support Technician, you support the department’s research and education activities by maintaining and improving computational and educational ICT services. You operate in a highly independent way and interact closely with researchers, PhD candidates, postdoctoral researchers and teaching staff in a dynamic and international work environment.

You contribute to solutions for storage and transfer of big data, while supporting hardware and operating systems across Windows, macOS and Linux environments. Your work includes the installation, maintenance and monitoring of Linux-based computational servers and supporting software development activities in Python, MATLAB, C++, CUDA and Fortran.

In addition, you help maintain and improve web-based educational and development tools such as JupyterBooks, MkDocs, Git and continuous integration environments. You act as a connecting link between the department and central ICT services at faculty and university level.

You will join a departmental support team of three highly-motivated technical professionals responsible for hardware, software and data-acquisition optimisation. Together, you strengthen the research infrastructure that enables approximately 30 staff members, 75 PhD candidates and 15 postdoctoral researchers to perform high-level research and education.

TU Delft offers a collaborative and internationally oriented working environment with opportunities for professional development, technical learning and collaboration with leading researchers in computational imaging and applied physics.

Job requirements

• You hold a BSc degree in Information Technology, Computer Science, or an equivalent technical field.
• You are comfortable supporting Windows, macOS and Linux operating systems.
• You have experience with Linux server installation, maintenance and user support.
• You have strong programming skills in at least one scientific programming language.
• You have affinity with research environments and supporting computational science workflows.
• You can work collaboratively with researchers, students and technical support colleagues.
• You communicate clearly in English, both spoken and written.
• You are willing to develop basic Dutch language skills; language courses are available through TU Delft.

Only candidates from EU countries or with a Dutch work permit can be considered for this vacancy (due to Dutch regulations).

TU Delft (Delft University of Technology)
Working at TU Delft means contributing to solutions that really make a difference.

For over 180 years, we have been training engineers who make an impact worldwide in companies, government bodies, or as entrepreneurs. Our alumni turn knowledge into concrete solutions for the challenges of today and tomorrow. These challenges are changing rapidly. That is why we focus on themes such as energy, climate, digitalisation, artificial intelligence (AI), and smart mobility every day. Our education and research are directly aligned with what society needs now and in the future.

At TU Delft, our people make the difference. With their knowledge and curiosity, our staff provide a high-quality education and conduct pioneering research that extends beyond the campus. You will have the opportunity to take the initiative, work with others, and grow as a professional. Working at TU Delft means join an international community of professionals and students. Together, we create knowledge, innovations, and solutions that help move the world forward.

Faculty Applied Sciences
With more than 1,100 employees, including 150 pioneering principal investigators, as well as a population of about 3,600 passionate students, the Faculty of Applied Sciences is an inspiring scientific ecosystem. Focusing on key enabling technologies, such as quantum- and nanotechnology, photonics, biotechnology, synthetic biology and materials for energy storage and conversion, our faculty aims to provide solutions to important problems of the 21st century. To that end, we educate innovative students in broad Bachelor's and specialist Master's programmes with a strong research component. Our scientists conduct ground-breaking fundamental and applied research in the fields of Life and Health Science & Technology, Nanoscience, Chemical Engineering, Radiation Science & Technology, and Engineering Physics. We are also training the next generation of high school teachers.

Click here to go to the website of the Faculty of Applied Sciences.

PhD student NUTRIMIND

Are you curious about whether mental health, gut microbiome and nutrition are connected? We are seeking a highly motivated PhD candidate to join NUTRIMIND, a Horizon-funded, multi-disciplinary project that investigates how diet and the microbiota-gut-brain axis might shape mental health across the lifespan. In collaboration with leading universities, research institutes, NGOs and SMEs across Europe, you will help unravel diet-linked risk signatures for depression, anxiety and stress, and translate these insights into practical, scalable strategies for prevention and care.

The project will consist of several work packages, and Wageningen University will be responsible for the work packages related to dietary exposures and mental health outcomes in existing studies. This primarily includes studies from Wageningen University and related partners (e.g. Wageningen Student Cohort, FINGER-NL, HELI, COMBI, and PRECODE but also from the United Kingdom, Spain and other countries).

As PhD student, your duties and responsibilities include:

• conduct data analyses of existing cohort and trial data to study association of dietary exposures and stress, anxiety and mental health outcomes;
• contribute to integration of broader biological data into the diet–mental health relationship by incorporating gut health indices (e.g. short‑chain fatty acids, intestinal permeability markers), omics data (untargeted metabolomics, proteomics) and neurobiological markers;
• plan and coordinate follow‑up waves of the Wageningen Student Cohort, including dietary assessment, sample collection (blood, faeces, urine) and mental health assessments using validated instruments;
• coordinate laboratory analyses of biofluid and fecal samples from the abovementioned studies;
• collaborate with partner institutes to standardize methods and contribute to data harmonization efforts across studysites

You will work here
The research is embedded within the chair groups of Global Nutrition (Professor Alida Melse-Boonstra), Nutritional Biology (Dr Yannick Vermeiren) and Nutrition and Disease (Dr Renate Winkels). Wageningen University (division Human Nutrition and Health) serves as an important consortium member of the European Horizon project called NUTRIMIND, which consists of 16 European consortium partners (link LinkedIn page chairholder or page at WUR site). You will be co-supervised by Dr Alida Melse-Boonstra, Dr Yannick Vermeiren, Dr Renate Winkels.