PhD Position in Single-Molecule Biophysic

Job description

We are looking for a PhD student passionate about understanding molecular mechanisms in biological systems. This position involves applying single-molecule techniques to study molecular interactions, including protein-ligand interactions and protein-peptide interactions. The candidate will work in an interdisciplinary environment, combining experimental approaches (single molecule fluorescence and biochemistry) with computational methods. The candidate will obtain single-molecule multiplexing data and validate machine learning predictions using the high-throughput data. The successful candidate will collaborate with international partners for therapeutic applications of this research. The project offers opportunities to make significant contributions to understanding molecular interactions and their implications for both fundamental and medical sciences.

Job requirements

• MSc degree (or nearing completion) in physics, biophysics, computational biology, or a related field.
• Strong programming skills (Python) and experience in data analysis and computational methods.
• Familiarity with molecular biology techniques.
• Excellent written and spoken English skills.
• Ability to work effectively in a collaborative, international, and interdisciplinary environment.

TU Delft (Delft University of Technology)
Delft University of Technology is built on strong foundations. As creators of the world-famous Dutch waterworks and pioneers in biotech, TU Delft is a top international university combining science, engineering and design. It delivers world class results in education, research and innovation to address challenges in the areas of energy, climate, mobility, health and digital society. For generations, our engineers have proven to be entrepreneurial problem-solvers, both in business and in a social context.

At TU Delft we embrace diversity as one of our core values and we actively engage to be a university where you feel at home and can flourish. We value different perspectives and qualities. We believe this makes our work more innovative, the TU Delft community more vibrant and the world more just. Together, we imagine, invent and create solutions using technology to have a positive impact on a global scale. That is why we invite you to apply. Your application will receive fair consideration.

Challenge. Change. Impact!

Faculty Applied Sciences
With more than 1,100 employees, including 150 pioneering principal investigators, as well as a population of about 3,600 passionate students, the Faculty of Applied Sciences is an inspiring scientific ecosystem. Focusing on key enabling technologies, such as quantum- and nanotechnology, photonics, biotechnology, synthetic biology and materials for energy storage and conversion, our faculty aims to provide solutions to important problems of the 21st century. To that end, we educate innovative students in broad Bachelor's and specialist Master's programmes with a strong research component. Our scientists conduct ground-breaking fundamental and applied research in the fields of Life and Health Science & Technology, Nanoscience, Chemical Engineering, Radiation Science & Technology, and Engineering Physics. We are also training the next generation of high school teachers.

Click here to go to the website of the Faculty of Applied Sciences.

Postdoc Physics of Cellular Robustness

Job description

Cells display a remarkable ability to adapt to strong genetic perturbations. In some cases, only a handful of mutations are sufficient to restore cellular function, even after major disruptions. This raises a fundamental question: how do cells reorganize their internal processes to buffer such perturbations and maintain functionality?

Within the ERC Consolidator Grant project PolarRobustness, we investigate the idea that cellular processes are not independent, but physically coupled. These couplings may allow processes to absorb and compensate for disturbances in each other, giving rise to a collective form of robustness. Understanding this requires moving beyond studying a single process in isolation, and instead capturing how multiple processes interact dynamically within the same cell.

In this postdoctoral project, you will in collaboration develop and apply an integrated experimental and theoretical framework to study multiple coupled cellular processes simultaneously. You will combine advanced live-cell microscopy with inference-based modeling to quantitatively describe how cells coordinate key processes over time.

You will work closely with an interdisciplinary team to establish a systems-level understanding of how coupled cellular processes collectively buffer perturbations.

Job requirements
The project will start in September and is embedded in the Laan Lab at the Department of Bionanoscience, Faculty of Applied Sciences, TU Delft. The lab offers a highly collaborative and international environment at the interface of physics and biology.

We are looking for a candidate with strong experience in live-cell microscopy and a keen interest in combining experiments with quantitative modeling to uncover fundamental principles of cellular organization and robustness. We expect the candidate to be a team-player, to have an independent and well-organized work style, to be communicative and creative, and to contribute to our open, interactive, and social lab culture.

TU Delft (Delft University of Technology)
Delft University of Technology is built on strong foundations. As creators of the world-famous Dutch waterworks and pioneers in biotech, TU Delft is a top international university combining science, engineering and design. It delivers world class results in education, research and innovation to address challenges in the areas of energy, climate, mobility, health and digital society. For generations, our engineers have proven to be entrepreneurial problem-solvers, both in business and in a social context.

At TU Delft we embrace diversity as one of our core values and we actively engage to be a university where you feel at home and can flourish. We value different perspectives and qualities. We believe this makes our work more innovative, the TU Delft community more vibrant and the world more just. Together, we imagine, invent and create solutions using technology to have a positive impact on a global scale. That is why we invite you to apply. Your application will receive fair consideration.

Challenge. Change. Impact!

Faculty Applied Sciences
With more than 1,100 employees, including 150 pioneering principal investigators, as well as a population of about 3,600 passionate students, the Faculty of Applied Sciences is an inspiring scientific ecosystem. Focusing on key enabling technologies, such as quantum- and nanotechnology, photonics, biotechnology, synthetic biology and materials for energy storage and conversion, our faculty aims to provide solutions to important problems of the 21st century. To that end, we educate innovative students in broad Bachelor's and specialist Master's programmes with a strong research component. Our scientists conduct ground-breaking fundamental and applied research in the fields of Life and Health Science & Technology, Nanoscience, Chemical Engineering, Radiation Science & Technology, and Engineering Physics. We are also training the next generation of high school teachers.

Click here to go to the website of the Faculty of Applied Sciences.

GZ-psycholoog/Regiebehandelaar

Van intake tot behandeling

Als Regiebehandelaar bij iHub ben je betrokken bij het hele zorgproces: van intake en consultatie tot diagnostiek, behandelplan en uitvoering van de behandeling. Je diagnosticeert, indiceert en behandelt kinderen en jongeren met uiteenlopende psychische problemen, zoals veiligheids- en hechtingsproblematiek, trauma’s, ADHD of persoonlijkheidsstoornissen.

iHub biedt basis, maar vooral specialistische jeugd-GGZ. De problematiek varieert van enkelvoudig tot zeer complex (zoals multi-stressgezinnen) en vraagt altijd om maatwerk. Niet het aanbod, maar de hulpvraag staat centraal: we doen wat nodig is om gezinnen te helpen hun leven weer op de rit te krijgen.

Samenwerken binnen een multidisciplinair team

Je werkt in een multidisciplinair team waarin verschillende specialisten, zoals vaktherapeuten en systeemtherapeuten, nauw samenwerken. Dit zorgt voor een integrale aanpak en voorkomt onnodige doorverwijzingen.

Als regiebehandelaar ben je verantwoordelijk voor een goed verloop van behandeltrajecten. Je:

• Voert intakes, anamneses en observaties uit.
• Doet psychodiagnostisch onderzoek en stelt behandelplannen op.
• Adviseert, voert behandelingen mede uit en bewaakt het zorgpad.
• Neemt deel aan intercollegiale overleggen.
• Je bent een stabiele factor in het team: je bewaart overzicht en rust, bent prettig in de omgang en collega’s weten je te vinden om te sparren.

Systemisch en outreachend werken

Je kijkt verder dan alleen het kind of de jongere en betrekt ook het gezin en sociale netwerk. Deze systemische benadering betekent dat je soms outreachend zal werken, waarbij je flexibel inspeelt op de situatie. Je denkt ruimdenkend en creatief in oplossingen, ook buiten de gebaande paden.

Ruimte voor groei en ontwikkeling

Je werkt in de regio Rijnmond en hebt veel vrijheid in het beheren van je agenda, zolang je je verantwoordelijkheden neemt. Er is volop ruimte voor persoonlijke en professionele groei, zowel als individueel behandelaar als regiebehandelaar.

Binnen iHUB, worden diverse cursussen en ontwikkeltrajecten aangeboden, zodat je je blijft ontwikkelen.

HBO Stage Social Work - Gezinscoach

Als stagiaire gezinscoach werk je mee aan het volledige proces van intake tot behandeling. Je voert intakes en consultaties uit, neemt deel aan (multidisciplinaire) overleggen, stelt behandelplannen op en ondersteunt bij de uitvoering van behandelingen. Samen met de regiebehandelaar geef je richting aan de begeleiding van cliënten en hun systeem.