PhD Position: Molecular Biology

Protein–protein interactions and dynamic protein states are important for cellular identity. Aberrations in proteins drive oncogenic signalling and disease progression. The goal of the Oncode Accelerator Growth Fund project is to accelerate the development of new cancer therapies. In this PhD project, you will employ existing proteomic tools and develop new ones to study protein interactions and signalling pathways in primary cancer tissues, organoids and clinical samples. A key aim is to connect molecular mechanisms to tumour biology and identify novel actionable targets for drug development.

You will work extensively with patient-derived FFPE material, which is readily available within our clinical network. You will optimise and implement proteomic workflows tailored for highly limited, heterogeneous samples, enabling in-depth profiling of tumour biology. A major component of your work will be to establish intratumoral heterogeneity maps using spatial proteomic profiling, including the use of laser capture microdissection to isolate defined tumour regions prior to mass spectrometry analysis. Where feasible, you will also explore single-cell proteomics approaches on patient samples to gain additional resolution on cell-state diversity within tumours.

In parallel, you will collaborate closely with a postdoctoral researcher to develop and apply novel proximity-labelling strategies to chart dynamic protein–protein interactions and local proteome environments. These methodological developments will feed directly into large-scale interaction and signalling network analyses across clinically annotated cohorts.

Together, these efforts will generate an unprecedented, high-resolution view of how cancer-specific protein interaction networks are rewired in human disease. The project’s findings are expected to inform new hypotheses on epigenetic control in cancer and contribute to Oncode Accelerator’s translational goals of identifying actionable molecular targets.

Your teaching load may be up to 10% of your working time.

Would you like to learn more about what it’s like to pursue a PhD at Radboud University? Visit the page about working as a PhD candidate.

PhD Position: Molecular Biology

Protein–protein interactions and dynamic protein states are important for cellular identity. Aberrations in proteins drive oncogenic signalling and disease progression. The goal of the Oncode Accelerator Growth Fund project is to accelerate the development of new cancer therapies. In this PhD project, you will employ existing proteomic tools and develop new ones to study protein interactions and signalling pathways in primary cancer tissues, organoids and clinical samples. A key aim is to connect molecular mechanisms to tumour biology and identify novel actionable targets for drug development.

You will work extensively with patient-derived FFPE material, which is readily available within our clinical network. You will optimise and implement proteomic workflows tailored for highly limited, heterogeneous samples, enabling in-depth profiling of tumour biology. A major component of your work will be to establish intratumoral heterogeneity maps using spatial proteomic profiling, including the use of laser capture microdissection to isolate defined tumour regions prior to mass spectrometry analysis. Where feasible, you will also explore single-cell proteomics approaches on patient samples to gain additional resolution on cell-state diversity within tumours.

In parallel, you will collaborate closely with a postdoctoral researcher to develop and apply novel proximity-labelling strategies to chart dynamic protein–protein interactions and local proteome environments. These methodological developments will feed directly into large-scale interaction and signalling network analyses across clinically annotated cohorts.

Together, these efforts will generate an unprecedented, high-resolution view of how cancer-specific protein interaction networks are rewired in human disease. The project’s findings are expected to inform new hypotheses on epigenetic control in cancer and contribute to Oncode Accelerator’s translational goals of identifying actionable molecular targets.

Your teaching load may be up to 10% of your working time.

Would you like to learn more about what it’s like to pursue a PhD at Radboud University? Visit the page about working as a PhD candidate.

PhD Position: Molecular Biology

Protein–protein interactions and dynamic protein states are important for cellular identity. Aberrations in proteins drive oncogenic signalling and disease progression. The goal of the Oncode Accelerator Growth Fund project is to accelerate the development of new cancer therapies. In this PhD project, you will employ existing proteomic tools and develop new ones to study protein interactions and signalling pathways in primary cancer tissues, organoids and clinical samples. A key aim is to connect molecular mechanisms to tumour biology and identify novel actionable targets for drug development.

You will work extensively with patient-derived FFPE material, which is readily available within our clinical network. You will optimise and implement proteomic workflows tailored for highly limited, heterogeneous samples, enabling in-depth profiling of tumour biology. A major component of your work will be to establish intratumoral heterogeneity maps using spatial proteomic profiling, including the use of laser capture microdissection to isolate defined tumour regions prior to mass spectrometry analysis. Where feasible, you will also explore single-cell proteomics approaches on patient samples to gain additional resolution on cell-state diversity within tumours.

In parallel, you will collaborate closely with a postdoctoral researcher to develop and apply novel proximity-labelling strategies to chart dynamic protein–protein interactions and local proteome environments. These methodological developments will feed directly into large-scale interaction and signalling network analyses across clinically annotated cohorts.

Together, these efforts will generate an unprecedented, high-resolution view of how cancer-specific protein interaction networks are rewired in human disease. The project’s findings are expected to inform new hypotheses on epigenetic control in cancer and contribute to Oncode Accelerator’s translational goals of identifying actionable molecular targets.

Your teaching load may be up to 10% of your working time.

Would you like to learn more about what it’s like to pursue a PhD at Radboud University? Visit the page about working as a PhD candidate.

Management- & office-assistent DCCN

Jouw takenpakket bestaat uit drie hoofdtaken. Ten eerste ben je samen met je collega’s het eerste aanspreekpunt van (nieuwe) medewerkers, gasten en leveranciers. Jij verwelkomt ze en maakt ze wegwijs binnen het Donders Centre for Cognitive Neuroimaging (DCCN). Ook het bijhouden van de gemeenschappelijke mailbox hoort bij deze taak. Tevens bied je secretariële ondersteuning aan het management team en de Principal Investigators (PI's) van het DCCN. Jouw taken zijn: agenda's beheren, afspraken inplannen en reizen boeken. Je bereidt eventueel vergaderstukken voor, bewaakt actiepunten of notuleert tijdens de vergadering. Ten derde organiseer je kleine en grote evenementen zoals de wekelijkse Research Update Meetings, colloquia of de Donders Toolkit, waarbij je in goed overleg zelfstandig aan de slag gaat.

Naast deze hoofdtaken verwachten we dat je bijspringt om je collega’s te ondersteunen met overige administratieve taken. Je komt te werken in een dynamische omgeving waardoor geen dag hetzelfde is. Je stapt de organisatie binnen op een uitdagend moment. Er wordt hard gewerkt aan het vastleggen en verbeteren van processen en taken. Samen werken we aan het behalen van de gemeenschappelijke doelstellingen van DCCN. Met jouw positieve energie vind jij hier makkelijk je weg in en maak je van DCCN je nieuwe thuis.

Management- & office-assistent DCCN

Jouw takenpakket bestaat uit drie hoofdtaken. Ten eerste ben je samen met je collega’s het eerste aanspreekpunt van (nieuwe) medewerkers, gasten en leveranciers. Jij verwelkomt ze en maakt ze wegwijs binnen het Donders Centre for Cognitive Neuroimaging (DCCN). Ook het bijhouden van de gemeenschappelijke mailbox hoort bij deze taak. Tevens bied je secretariële ondersteuning aan het management team en de Principal Investigators (PI's) van het DCCN. Jouw taken zijn: agenda's beheren, afspraken inplannen en reizen boeken. Je bereidt eventueel vergaderstukken voor, bewaakt actiepunten of notuleert tijdens de vergadering. Ten derde organiseer je kleine en grote evenementen zoals de wekelijkse Research Update Meetings, colloquia of de Donders Toolkit, waarbij je in goed overleg zelfstandig aan de slag gaat.

Naast deze hoofdtaken verwachten we dat je bijspringt om je collega’s te ondersteunen met overige administratieve taken. Je komt te werken in een dynamische omgeving waardoor geen dag hetzelfde is. Je stapt de organisatie binnen op een uitdagend moment. Er wordt hard gewerkt aan het vastleggen en verbeteren van processen en taken. Samen werken we aan het behalen van de gemeenschappelijke doelstellingen van DCCN. Met jouw positieve energie vind jij hier makkelijk je weg in en maak je van DCCN je nieuwe thuis.